ADSS
Gene Information
- Official Symbol: ADSS2
- Official Name: adenylosuccinate synthase 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 159
- UniProt: P30520
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.
Pfam Domains GO Terms
Pfam Domains
| Adenylsucc synt |
GO Terms
| adenylosuccinate synthase activity |
| de novo AMP biosynthetic process |
| AMP biosynthetic process |
| aspartate metabolic process |
| phosphate ion binding |
| cellular response to electrical stimulus |
| IMP metabolic process |
| AMP metabolic process |
| purine nucleoside monophosphate biosynthetic process |
| purine ribonucleoside monophosphate biosynthetic process |
| ribonucleoside monophosphate biosynthetic process |
| purine ribonucleoside monophosphate metabolic process |
| purine nucleoside monophosphate metabolic process |
| response to electrical stimulus |
| nucleoside monophosphate biosynthetic process |
| ribonucleoside monophosphate metabolic process |
| aspartate family amino acid metabolic process |
| nucleoside monophosphate metabolic process |
| dicarboxylic acid metabolic process |
| purine ribonucleotide biosynthetic process |
| response to purine-containing compound |
| purine nucleotide biosynthetic process |
| ribonucleotide biosynthetic process |
| ribose phosphate biosynthetic process |
| purine-containing compound biosynthetic process |
| response to ammonium ion |
| alpha-amino acid metabolic process |
| magnesium ion binding |
| nucleotide biosynthetic process |
| nucleoside phosphate biosynthetic process |
| cellular amino acid metabolic process |
| purine ribonucleotide metabolic process |
| cellular response to abiotic stimulus |
| cellular response to environmental stimulus |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| purine-containing compound metabolic process |
| GTP binding |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| drug metabolic process |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| carbohydrate derivative biosynthetic process |
| organophosphate metabolic process |
| carboxylic acid metabolic process |
| response to organic cyclic compound |
| response to organonitrogen compound |
| oxoacid metabolic process |
| organic acid metabolic process |
| carbohydrate derivative metabolic process |
| response to nitrogen compound |
| nucleobase-containing compound biosynthetic process |
| response to abiotic stimulus |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| organic cyclic compound biosynthetic process |
| organonitrogen compound biosynthetic process |
| cellular nitrogen compound biosynthetic process |
| small molecule metabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 26/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 2/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 1/13 |
| fibroblast | 0/1 |
| gastric | 2/16 |
| kidney | 1/21 |
| liver | 0/20 |
| lung | 4/75 |
| lymphocyte | 2/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 5/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 1/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 638
- Expression level (log2 read counts): 5.89
Expression Distribution
ADSS Expression in NALM6 Cells: 5.89
