ANKRD49

Entrez Summary: N/A
UniProt Summary: Induces HBG1 expression (PubMed:16131492, PubMed:11162141). May have a role in spermatogenesis where it promotes autophagy in response to serum starvation, via the NF- kappaB pathway (By similarity). {ECO:0000250|UniProtKB:Q8VE42, ECO:0000269|PubMed:11162141, ECO:0000269|PubMed:16131492}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.76
Dimethyloxaloylglycine 100μM R05 exp229	1.8
Vemurafenib 6.6μM R08 exp434	2.54

Gene	Correlation
FKBPL	0.556
TOMM70A	0.408

Global Fraction of Cell Lines Where Essential: 81/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	3/28
blood	2/28
bone	0/26
breast	4/33
central nervous system	1/56
cervix	1/4
colorectal	3/17
esophagus	3/13
fibroblast	0/1
gastric	1/16
kidney	5/21
liver	3/20
lung	7/75
lymphocyte	1/16
ovary	3/26
pancreas	6/24
peripheral nervous system	2/16
plasma cell	0/15
prostate	0/1
skin	3/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	7/22
urinary tract	3/29
uterus	0/5

Expression Distribution