TOMM70A

Entrez Summary: N/A
UniProt Summary: Receptor that accelerates the import of all mitochondrial precursor proteins. {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Etoposide 1μM R00 exp19	-2.08
Dinaciclib 0.007μM R07 exp355	-2.02
Rotenone 2μM R00 exp33	-1.87
Etoposide 0.3μM R05 exp199	-1.82
Latrunculin-B 10μM R07 exp374	-1.8
BI-6727 0.04μM R03 exp98	-1.77
Hydroxyurea 15μM R06 exp289	1.89
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.91

Global Fraction of Cell Lines Where Essential: 3/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

TPR 1
TPR 2

mitochondrial outer membrane translocase complex
protein transmembrane transporter activity
protein targeting to mitochondrion
protein transmembrane transport
establishment of protein localization to mitochondrion
protein localization to mitochondrion
macroautophagy
mitochondrial outer membrane
mitochondrial transport
autophagy
process utilizing autophagic mechanism
protein targeting
establishment of protein localization to organelle
mitochondrion organization
protein localization to organelle
intracellular protein transport
mitochondrion
transmembrane transport
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
cellular catabolic process
establishment of localization in cell
nitrogen compound transport
membrane