ARHGEF10

Entrez Summary: This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
UniProt Summary: May play a role in developmental myelination of peripheral nerves. {ECO:0000269|PubMed:14508709}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Oligomycin-A 2μM R00 exp25	-2.29
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	-2.02
5-Fluorouracil 2μM R00 exp1	-1.95
Rotenone 20μM R00 exp34	-1.91
Pimelic-diphenylamide-106 5μM R00 exp28	-1.88
Rapamycin 10μM R00 exp30	-1.8
CCCP 0.1μM R00 exp10	-1.78
Heregulin-B 44ng/ml R08 exp486	-1.71
BS-181 20μM R08 exp461	1.76
Etoposide 0.3μM R05 exp199	1.82
Bleomycin 5μM R08 exp459	2.03
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	2.05

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution