ATL2

Entrez Summary: N/A
UniProt Summary: GTPase tethering membranes through formation of trans- homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis (PubMed:18270207, PubMed:19665976, PubMed:27619977). {ECO:0000269|PubMed:18270207, ECO:0000269|PubMed:19665976, ECO:0000269|PubMed:27619977}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Dynasore 7μM R08 exp436	-2.48
Brefeldin A 0.02μM R00 exp8	-2.34
Cerivastatin 0.15μM R05 exp226	-2.29
Oligomycin-A 20μM R00 exp26	-1.76
UM0125461 0.74μM R02 exp84	-1.7
∆-9-Tetrahydrocannabinol 30μM R08 exp445	1.92
YM155 0.0002μM R01 exp61	1.93
RK-33 8μM R08 exp518	1.98
Vemurafenib 6.6μM R08 exp434	2.49

Gene	Correlation
HGC6.3	0.559

Global Fraction of Cell Lines Where Essential: 213/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	6/28
blood	9/28
bone	7/26
breast	7/33
central nervous system	18/56
cervix	0/4
colorectal	5/17
esophagus	2/13
fibroblast	1/1
gastric	4/16
kidney	6/21
liver	9/20
lung	16/75
lymphocyte	7/16
ovary	8/26
pancreas	3/24
peripheral nervous system	7/16
plasma cell	2/15
prostate	0/1
skin	12/24
soft tissue	4/9
thyroid	0/2
upper aerodigestive	7/22
urinary tract	10/29
uterus	2/5

Expression Distribution