AWAT1
Gene Information
- Official Symbol: AWAT1
- Official Name: acyl-CoA wax alcohol acyltransferase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 158833
- UniProt: Q58HT5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene belongs to the diacylglycerol acyltransferase family. It esterifies long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that this enzyme plays a central role in lipid metabolism in skin. Consistent with this observation, this protein is predominantly expressed in the sebaceous gland of the skin. [provided by RefSeq, Sep 2009].
- UniProt Summary: Acyltransferase that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters. Wax esters are enriched in sebum, suggesting that it plays a central role in lipid metabolism in skin. Has a preference for arachidyl alcohol as well as decyl alcohol, demonstrating its relatively poor activity using saturated long chain alcohols (C16, C18, and C20). {ECO:0000269|PubMed:15671038}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 11620
- Expression level (log2 read counts): -5.6
AWAT1 Expression in NALM6 Cells: -5.6
