BCL2L2
Gene Information
- Official Symbol: BCL2L2
- Official Name: BCL2 like 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 599
- UniProt: Q92843
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX. {ECO:0000269|PubMed:8761287}.
Pfam Domains GO Terms
Pfam Domains
| BH4 |
| Bcl-2 |
GO Terms
| BH domain binding |
| Sertoli cell proliferation |
| Bcl-2 family protein complex |
| signal transduction in absence of ligand |
| extrinsic apoptotic signaling pathway in absence of ligand |
| disordered domain specific binding |
| cellular response to estradiol stimulus |
| cellular response to amyloid-beta |
| response to amyloid-beta |
| intrinsic apoptotic signaling pathway in response to DNA damage |
| epithelial cell proliferation |
| negative regulation of intrinsic apoptotic signaling pathway |
| extrinsic apoptotic signaling pathway |
| male gonad development |
| development of primary male sexual characteristics |
| response to estradiol |
| intrinsic apoptotic signaling pathway |
| male sex differentiation |
| regulation of intrinsic apoptotic signaling pathway |
| mitochondrial outer membrane |
| gonad development |
| development of primary sexual characteristics |
| negative regulation of apoptotic signaling pathway |
| sex differentiation |
| apoptotic signaling pathway |
| cellular response to peptide |
| regulation of apoptotic signaling pathway |
| reproductive structure development |
| reproductive system development |
| response to peptide |
| protein heterodimerization activity |
| negative regulation of intracellular signal transduction |
| cellular response to lipid |
| cellular response to organic cyclic compound |
| spermatogenesis |
| cell population proliferation |
| male gamete generation |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| cellular response to nitrogen compound |
| developmental process involved in reproduction |
| gamete generation |
| cellular response to DNA damage stimulus |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| response to lipid |
| protein homodimerization activity |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| response to hormone |
| response to organic cyclic compound |
| apoptotic process |
| negative regulation of cell death |
| multi-organism reproductive process |
| response to organonitrogen compound |
| programmed cell death |
| cellular response to oxygen-containing compound |
| identical protein binding |
| response to nitrogen compound |
| cell death |
| cellular response to endogenous stimulus |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| reproductive process |
| reproduction |
| response to endogenous stimulus |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| negative regulation of response to stimulus |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| regulation of intracellular signal transduction |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Benzoate 20000μM R08 exp456 | -1.7 |
| YM155 0.0002μM R01 exp61 | 1.87 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2460
- Expression level (log2 read counts): 4.62
Expression Distribution
BCL2L2 Expression in NALM6 Cells: 4.62
