BOLA3
Gene Information
- Official Symbol: BOLA3
- Official Name: bolA family member 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 388962
- UniProt: Q53S33
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a protein that plays an essential role in the production of iron-sulfur (Fe-S) clusters for the normal maturation of lipoate-containing 2-oxoacid dehydrogenases, and for the assembly of the mitochondrial respiratory chain complexes. Mutation in this gene has been associated with multiple mitochondrial dysfunctions syndrome-2. Two alternatively spliced transcript variants encoding different isoforms with distinct subcellular localization have been reported for this gene (PMID:21944046). [provided by RefSeq, Dec 2011].
- UniProt Summary: Acts as a mitochondrial iron-sulfur (Fe-S) cluster assembly factor that facilitates (Fe-S) cluster insertion into a subset of mitochondrial proteins. Probably acts together with NFU1 (PubMed:27532772). {ECO:0000250|UniProtKB:P39724, ECO:0000305|PubMed:27532772}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 12171
- Expression level (log2 read counts): 3.78
BOLA3 Expression in NALM6 Cells: 3.78
