UniProt Summary: CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.
Pfam DomainsGO Terms
Pfam Domains
Calc CGRP IAPP
GO Terms
calcitonin receptor binding
neuropeptide hormone activity
cell
adenylate cyclase-activating G protein-coupled receptor signaling pathway
cAMP-mediated signaling
cyclic-nucleotide-mediated signaling
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
regulation of cytosolic calcium ion concentration
second-messenger-mediated signaling
cellular calcium ion homeostasis
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
divalent inorganic cation homeostasis
cellular metal ion homeostasis
metal ion homeostasis
cellular cation homeostasis
cellular ion homeostasis
cation homeostasis
inorganic ion homeostasis
cellular chemical homeostasis
ion homeostasis
cellular homeostasis
chemical homeostasis
G protein-coupled receptor signaling pathway
extracellular space
homeostatic process
intracellular signal transduction
extracellular region
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)