CATSPER3

Entrez Summary: N/A
UniProt Summary: Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rotenone 0.07μM R08 exp431	-1.88
MK-1775 0.32μM R02 exp75	-1.79
S-DABN 8μM R03 exp112	1.73
Hypoxia 5%O2 R04 exp191	1.75
Demecolcine 0.03μM R05 exp228	1.75
Arsenic trioxide 60μM R08 exp449	1.76
Cholesterol 0.003 to 0.006 to 0.1μM on day2 then day6 R08 exp471	1.78
UM0131023 0.05μM R05 exp248	1.91
RO-3306 3 to 4μM on day4 R04 exp165	1.95
IU1-C 25μM R04 exp183	1.97
Docetaxel 0.001 to 0.002μM on day4 R04 exp159	2.19
TNF-alpha 44ng/ml R08 exp533	2.2
CyclicAMP 200μM R08 exp475	2.47

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution