CCAR1
Gene Information
- Official Symbol: CCAR1
- Official Name: cell division cycle and apoptosis regulator 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 55749
- UniProt: Q8IX12
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| SAP |
GO Terms
| nuclear receptor transcription coactivator activity |
| RNA polymerase II distal enhancer sequence-specific DNA binding |
| transcription corepressor activity |
| transcription coactivator activity |
| RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| mRNA splicing, via spliceosome |
| RNA splicing, via transesterification reactions |
| RNA splicing |
| mRNA processing |
| positive regulation of cell migration |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| positive regulation of locomotion |
| mRNA metabolic process |
| perinuclear region of cytoplasm |
| regulation of cell migration |
| RNA processing |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| apoptotic process |
| regulation of locomotion |
| regulation of cellular component movement |
| programmed cell death |
| cell death |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| cell cycle |
| RNA binding |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| regulation of cell population proliferation |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| RNA metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| CB-5083 0.4μM R08 exp468 | -2.16 |
| Dynasore 7μM R08 exp436 | -2.15 |
| Diepoxybutane 3μM R07 exp354 | -2.1 |
| DABN racemic mixture R03 exp93 | -1.83 |
| GSK626616 14μM R08 exp485 | -1.82 |
| UM131593 0.2μM R03 exp106 | -1.82 |
| UM0125461 0.74μM R02 exp84 | -1.79 |
| DABN 2μM R00 exp16 | 1.75 |
| Clomiphene 4.4μM R02 exp68 | 1.85 |
| Latrunculin-B 10μM R07 exp374 | 1.99 |
| CR131-b 0.005μM R08 exp474 | 4.29 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 182/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 1/1 |
| bile duct | 7/28 |
| blood | 7/28 |
| bone | 5/25 |
| breast | 6/33 |
| central nervous system | 9/56 |
| cervix | 2/4 |
| colorectal | 5/17 |
| esophagus | 4/13 |
| fibroblast | 1/1 |
| gastric | 3/15 |
| kidney | 4/21 |
| liver | 8/20 |
| lung | 21/75 |
| lymphocyte | 1/14 |
| ovary | 8/26 |
| pancreas | 6/24 |
| peripheral nervous system | 8/16 |
| plasma cell | 1/15 |
| prostate | 1/1 |
| skin | 5/24 |
| soft tissue | 2/7 |
| thyroid | 0/2 |
| upper aerodigestive | 11/22 |
| urinary tract | 10/29 |
| uterus | 2/5 |
Essentiality in NALM6
- Essentiality Rank: 1565
- Expression level (log2 read counts): 8.08
Expression Distribution
CCAR1 Expression in NALM6 Cells: 8.08
