CCZ1

Gene Information

Official Symbol: CCZ1
Official Name: CCZ1 homolog, vacuolar protein trafficking and biogenesis associated
Aliases and Previous Symbols: N/A
Entrez ID: 51622
UniProt: P86791
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Acts in concert with MON1A, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form (PubMed:23084991). {ECO:0000269|PubMed:23084991}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
DABN racemic mixture R03 exp93	1.84
Nocodazole 0.2μM R02 exp64	1.89
Vinblastine 0.015μM R05 exp208	1.96
Betulinic acid 10 to 15μM on day4 R05 exp222	2
Rotenone 2μM R00 exp33	2.05
R-DABN 8μM R03 exp111	2.09
HMS-I1 10μM R06 exp256	2.12
SB743921 0.001μM R05 exp244	2.13
BI-6727 0.04μM R03 exp98	2.32
LJH685 50μM R08 exp433	2.37
Nocodazole 0.1μM R03 exp94	2.69
Nocodazole 0.2μM R00 exp24	3.83

Essentiality in NALM6

Essentiality Rank: 4254
Expression level (log2 read counts): 6.04

Expression Distribution