Entrez Summary: This gene encodes a protein that appears to play a role in nuclear envelope integrity, possibly related to microtubule attachments. Mutations in this gene cause congenital dyserythropoietic anemia type I, a disease resulting in morphological and functional abnormalities of erythropoiesis. [provided by RefSeq, Jul 2009].
UniProt Summary: May act as a negative regulator of ASF1 in chromatin assembly. {ECO:0000269|PubMed:22407294}.
Pfam DomainsGO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
negative regulation of DNA replication
endomembrane system
regulation of DNA replication
chromatin assembly
chromatin assembly or disassembly
DNA packaging
DNA conformation change
chromatin organization
chromosome organization
negative regulation of cellular macromolecule biosynthetic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)