UniProt Summary: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. {ECO:0000269|PubMed:14536089, ECO:0000269|PubMed:16875666, ECO:0000269|PubMed:18007590}.
Pfam DomainsGO Terms
Pfam Domains
CENP-H
GO Terms
kinetochore binding
kinetochore assembly
kinetochore organization
CENP-A containing chromatin organization
CENP-A containing nucleosome assembly
chromatin remodeling at centromere
centromere complex assembly
DNA replication-independent nucleosome assembly
DNA replication-independent nucleosome organization
histone exchange
ATP-dependent chromatin remodeling
kinetochore
condensed chromosome kinetochore
nucleosome assembly
chromatin assembly
chromatin assembly or disassembly
nucleosome organization
chromatin remodeling
DNA packaging
protein-DNA complex assembly
protein-DNA complex subunit organization
DNA conformation change
chromatin organization
organelle assembly
cellular protein-containing complex assembly
nucleolus
chromosome organization
protein-containing complex assembly
protein-containing complex subunit organization
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)