CERK

Entrez Summary: N/A
UniProt Summary: Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides. {ECO:0000269|PubMed:19168031}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cyclosporin-A 0.8μM R07 exp347	-2.03
EPZ-5676 30μM R05 exp233	-1.95
Dimethyl-Sulfoxide 1pc R03 exp120	-1.78
KU-0063794 3.8μM R02 exp71	-1.74
Vinorelbine 0.001μM R05 exp249	1.75
Dynasore 7μM R08 exp436	1.82
CR131-b 0.005μM R08 exp474	2.04
MLN-4924 0.2μM R00 exp21	2.05
Docosahexaenoic-acid 50μM R07 exp356	2.12
YM155 0.001μM R08 exp432	2.19

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution