Pfam Domains GO Terms
| Cofilin ADF |
| actin filament fragmentation |
| neural fold formation |
| actin filament depolymerization |
| positive regulation of actin filament depolymerization |
| positive regulation by host of viral process |
| morphogenesis of an epithelial fold |
| positive regulation of protein depolymerization |
| lamellipodium membrane |
| modulation by host of viral process |
| protein depolymerization |
| positive regulation of protein complex disassembly |
| regulation of dendritic spine morphogenesis |
| interleukin-12-mediated signaling pathway |
| cellular response to interleukin-12 |
| response to interleukin-12 |
| actin polymerization or depolymerization |
| regulation of actin filament depolymerization |
| cortical actin cytoskeleton |
| neural crest cell migration |
| mitotic cytokinesis |
| modification by host of symbiont morphology or physiology |
| regulation of dendritic spine development |
| interaction with symbiont |
| Rho protein signal transduction |
| neural crest cell development |
| mesenchymal cell development |
| regulation of protein depolymerization |
| stem cell development |
| neural crest cell differentiation |
| regulation of dendrite morphogenesis |
| ruffle membrane |
| cytoskeleton-dependent cytokinesis |
| regulation of postsynapse organization |
| primary neural tube formation |
| cytokinesis |
| neural tube formation |
| positive regulation of viral process |
| nuclear matrix |
| modification of morphology or physiology of other organism involved in symbiotic interaction |
| regulation of protein complex disassembly |
| response to amino acid |
| establishment of cell polarity |
| embryonic epithelial tube formation |
| epithelial tube formation |
| cellular protein complex disassembly |
| vesicle |
| morphogenesis of embryonic epithelium |
| tube formation |
| regulation of dendrite development |
| modification of morphology or physiology of other organism |
| mesenchymal cell differentiation |
| stem cell differentiation |
| neural tube development |
| cell-cell junction |
| ameboidal-type cell migration |
| lamellipodium |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| establishment or maintenance of cell polarity |
| positive regulation of supramolecular fiber organization |
| actin filament binding |
| regulation of viral process |
| regulation of synapse organization |
| regulation of symbiosis, encompassing mutualism through parasitism |
| positive regulation of cytoskeleton organization |
| mesenchyme development |
| regulation of synapse structure or activity |
| actin filament organization |
| protein-containing complex disassembly |
| Ras protein signal transduction |
| regulation of actin filament organization |
| response to virus |
| regulation of cell morphogenesis involved in differentiation |
| epithelial tube morphogenesis |
| small GTPase mediated signal transduction |
| signaling receptor binding |
| regulation of actin cytoskeleton organization |
| response to acid chemical |
| regulation of supramolecular fiber organization |
| regulation of cellular component size |
| regulation of actin filament-based process |
| cellular component disassembly |
| focal adhesion |
| morphogenesis of an epithelium |
| supramolecular fiber organization |
| regulation of cell morphogenesis |
| cell division |
| actin cytoskeleton organization |
| regulation of neuron projection development |
| positive regulation of multi-organism process |
| regulation of anatomical structure size |
| regulation of cytoskeleton organization |
| tissue morphogenesis |
| embryonic morphogenesis |
| actin filament-based process |
| mitotic cell cycle process |
| positive regulation of organelle organization |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| regulation of neuron differentiation |
| cytokine-mediated signaling pathway |
| mitotic cell cycle |
| regulation of plasma membrane bounded cell projection organization |
| regulation of cell projection organization |
| regulation of multi-organism process |
| symbiotic process |
| regulation of neurogenesis |
| interspecies interaction between organisms |
| tube development |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| regulation of nervous system development |
| regulation of cell development |
| cell migration |
| protein phosphorylation |
| embryo development |
| negative regulation of cell death |
| cell cycle process |
| response to organonitrogen compound |
| cellular response to cytokine stimulus |
| regulation of anatomical structure morphogenesis |
| cell motility |
| localization of cell |
| response to nitrogen compound |
| response to cytokine |
| cytoskeleton organization |
| epithelium development |
| positive regulation of cellular component organization |
| phosphorylation |
| regulation of organelle organization |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| response to biotic stimulus |
| cell cycle |
| generation of neurons |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| extracellular space |
| neurogenesis |
| cell development |
| regulation of cell death |
| intracellular signal transduction |
| tissue development |
| regulation of cell differentiation |
| protein-containing complex subunit organization |
| membrane |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 7/28 |
| blood | 10/28 |
| bone | 3/26 |
| breast | 5/33 |
| central nervous system | 2/56 |
| cervix | 0/4 |
| colorectal | 5/17 |
| esophagus | 7/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 1/21 |
| liver | 1/20 |
| lung | 11/75 |
| lymphocyte | 12/16 |
| ovary | 4/26 |
| pancreas | 4/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 10/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 1/9 |
| thyroid | 0/2 |
| upper aerodigestive | 8/22 |
| urinary tract | 3/29 |
| uterus | 0/5 |
Expression Distribution