CNOT10
Gene Information
- Official Symbol: CNOT10
- Official Name: CCR4-NOT transcription complex subunit 10
- Aliases and Previous Symbols: N/A
- Entrez ID: 25904
- UniProt: Q9H9A5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| CCR4-NOT complex |
| nuclear-transcribed mRNA poly(A) tail shortening |
| DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| signal transduction involved in mitotic DNA integrity checkpoint |
| signal transduction involved in mitotic cell cycle checkpoint |
| signal transduction involved in mitotic G1 DNA damage checkpoint |
| signal transduction involved in mitotic DNA damage checkpoint |
| intracellular signal transduction involved in G1 DNA damage checkpoint |
| nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| mitotic G1/S transition checkpoint |
| mitotic G1 DNA damage checkpoint |
| G1 DNA damage checkpoint |
| signal transduction involved in DNA damage checkpoint |
| signal transduction involved in DNA integrity checkpoint |
| signal transduction involved in cell cycle checkpoint |
| DNA damage response, signal transduction by p53 class mediator |
| positive regulation of cell cycle arrest |
| gene silencing by RNA |
| mitotic DNA damage checkpoint |
| negative regulation of G1/S transition of mitotic cell cycle |
| signal transduction in response to DNA damage |
| mitotic DNA integrity checkpoint |
| negative regulation of cell cycle G1/S phase transition |
| regulation of cell cycle arrest |
| signal transduction by p53 class mediator |
| negative regulation of translation |
| DNA damage checkpoint |
| DNA integrity checkpoint |
| negative regulation of cellular amide metabolic process |
| regulation of G1/S transition of mitotic cell cycle |
| gene silencing |
| mitotic cell cycle checkpoint |
| regulation of cell cycle G1/S phase transition |
| cell cycle checkpoint |
| nuclear-transcribed mRNA catabolic process |
| negative regulation of mitotic cell cycle phase transition |
| mRNA catabolic process |
| negative regulation of cell cycle phase transition |
| RNA catabolic process |
| positive regulation of cell cycle process |
| negative regulation of mitotic cell cycle |
| negative regulation of cell cycle process |
| regulation of translation |
| nucleobase-containing compound catabolic process |
| positive regulation of cell cycle |
| regulation of cellular amide metabolic process |
| regulation of mitotic cell cycle phase transition |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| aromatic compound catabolic process |
| regulation of cell cycle phase transition |
| organic cyclic compound catabolic process |
| posttranscriptional regulation of gene expression |
| negative regulation of cell cycle |
| mitotic cell cycle process |
| regulation of mitotic cell cycle |
| mitotic cell cycle |
| mRNA metabolic process |
| regulation of cell cycle process |
| cellular response to DNA damage stimulus |
| cellular macromolecule catabolic process |
| cell cycle process |
| negative regulation of cellular protein metabolic process |
| macromolecule catabolic process |
| negative regulation of protein metabolic process |
| regulation of cell cycle |
| cell cycle |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| RNA metabolic process |
| intracellular signal transduction |
| cellular response to stress |
| negative regulation of gene expression |
| organic substance catabolic process |
| cellular catabolic process |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Ribavirin 10μM R01 exp52 | -1.89 |
| YM155 0.0002μM R01 exp61 | -1.83 |
| AICAR 240μM R03 exp116 | -1.81 |
| Staurosporine 0.02μM R08 exp524 | -1.71 |
| TRAIL 5ng/ml R00 exp35 | 1.71 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2099
- Expression level (log2 read counts): 5.65
Expression Distribution
CNOT10 Expression in NALM6 Cells: 5.65
