COX5B
Gene Information
- Official Symbol: COX5B
- Official Name: cytochrome c oxidase subunit 5B
- Aliases and Previous Symbols: N/A
- Entrez ID: 1329
- UniProt: P10606
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Pfam Domains GO Terms
Pfam Domains
| COX5B |
GO Terms
| aerobic electron transport chain |
| mitochondrial electron transport, cytochrome c to oxygen |
| mitochondrial ATP synthesis coupled proton transport |
| energy coupled proton transport, down electrochemical gradient |
| ATP synthesis coupled proton transport |
| cytochrome-c oxidase activity |
| ATP biosynthetic process |
| respiratory gaseous exchange by respiratory system |
| purine ribonucleoside triphosphate biosynthetic process |
| purine nucleoside triphosphate biosynthetic process |
| ribonucleoside triphosphate biosynthetic process |
| purine ribonucleoside triphosphate metabolic process |
| nucleoside triphosphate biosynthetic process |
| ribonucleoside triphosphate metabolic process |
| purine nucleoside triphosphate metabolic process |
| aerobic respiration |
| mitochondrial ATP synthesis coupled electron transport |
| ATP synthesis coupled electron transport |
| mitochondrial transmembrane transport |
| nucleoside triphosphate metabolic process |
| respiratory electron transport chain |
| oxidative phosphorylation |
| proton transmembrane transport |
| purine ribonucleotide biosynthetic process |
| purine nucleotide biosynthetic process |
| ribonucleotide biosynthetic process |
| cellular respiration |
| ribose phosphate biosynthetic process |
| purine-containing compound biosynthetic process |
| electron transport chain |
| ATP metabolic process |
| mitochondrial transport |
| energy derivation by oxidation of organic compounds |
| nucleotide biosynthetic process |
| nucleoside phosphate biosynthetic process |
| purine ribonucleotide metabolic process |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| purine-containing compound metabolic process |
| mitochondrial inner membrane |
| monovalent inorganic cation transport |
| generation of precursor metabolites and energy |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| drug metabolic process |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| inorganic cation transmembrane transport |
| cation transmembrane transport |
| carbohydrate derivative biosynthetic process |
| inorganic ion transmembrane transport |
| cation transport |
| organophosphate metabolic process |
| ion transmembrane transport |
| oxidation-reduction process |
| carbohydrate derivative metabolic process |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| mitochondrion |
| transmembrane transport |
| phosphorylation |
| organic cyclic compound biosynthetic process |
| ion transport |
| organonitrogen compound biosynthetic process |
| intracellular transport |
| cellular nitrogen compound biosynthetic process |
| small molecule metabolic process |
| establishment of localization in cell |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 55/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 4/28 |
| bone | 3/26 |
| breast | 4/33 |
| central nervous system | 2/56 |
| cervix | 1/4 |
| colorectal | 3/17 |
| esophagus | 2/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 3/21 |
| liver | 0/20 |
| lung | 7/75 |
| lymphocyte | 2/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 1/15 |
| prostate | 0/1 |
| skin | 2/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 4/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1024
- Expression level (log2 read counts): 6.36
Expression Distribution
COX5B Expression in NALM6 Cells: 6.36
