CSPG5
Gene Information
- Official Symbol: CSPG5
- Official Name: chondroitin sulfate proteoglycan 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 10675
- UniProt: O95196
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a proteoglycan that may function as a neural growth and differentiation factor. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011].
- UniProt Summary: May function as a growth and differentiation factor involved in neuritogenesis. May induce ERBB3 activation. {ECO:0000269|PubMed:15358134}.
Pfam Domains GO Terms
Pfam Domains
| Neural ProG Cyt |
| Chon Sulph att |
GO Terms
| glial cell projection elongation |
| trans-synaptic signaling, modulating synaptic transmission |
| dermatan sulfate biosynthetic process |
| dermatan sulfate metabolic process |
| chondroitin sulfate catabolic process |
| dermatan sulfate proteoglycan biosynthetic process |
| dermatan sulfate proteoglycan metabolic process |
| Golgi-associated vesicle membrane |
| chondroitin sulfate biosynthetic process |
| chondroitin sulfate proteoglycan biosynthetic process |
| positive regulation of substrate adhesion-dependent cell spreading |
| chondroitin sulfate metabolic process |
| chondroitin sulfate proteoglycan metabolic process |
| integral component of postsynaptic membrane |
| regulation of substrate adhesion-dependent cell spreading |
| sulfur compound catabolic process |
| glycosaminoglycan catabolic process |
| aminoglycan catabolic process |
| GABA-ergic synapse |
| proteoglycan biosynthetic process |
| regulation of synaptic vesicle exocytosis |
| proteoglycan metabolic process |
| lysosomal lumen |
| Golgi lumen |
| glycosaminoglycan biosynthetic process |
| regulation of neurotransmitter secretion |
| glial cell development |
| mucopolysaccharide metabolic process |
| aminoglycan biosynthetic process |
| regulation of synaptic vesicle cycle |
| positive regulation of cell-substrate adhesion |
| regulation of neurotransmitter transport |
| positive regulation of cell morphogenesis involved in differentiation |
| glycosaminoglycan metabolic process |
| regulation of regulated secretory pathway |
| growth factor activity |
| aminoglycan metabolic process |
| glial cell differentiation |
| sulfur compound biosynthetic process |
| monocarboxylic acid biosynthetic process |
| carbohydrate derivative catabolic process |
| regulation of cell-substrate adhesion |
| gliogenesis |
| regulation of exocytosis |
| carboxylic acid biosynthetic process |
| regulation of cell morphogenesis involved in differentiation |
| organic acid biosynthetic process |
| glycoprotein biosynthetic process |
| glutamatergic synapse |
| regulation of neurotransmitter levels |
| sulfur compound metabolic process |
| glycoprotein metabolic process |
| positive regulation of cell adhesion |
| trans-synaptic signaling |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| synaptic signaling |
| cell projection morphogenesis |
| regulation of cell morphogenesis |
| drug metabolic process |
| cell part morphogenesis |
| monocarboxylic acid metabolic process |
| positive regulation of cell development |
| regulation of vesicle-mediated transport |
| small molecule biosynthetic process |
| cell surface |
| carbohydrate derivative biosynthetic process |
| Golgi membrane |
| regulation of growth |
| regulation of cell adhesion |
| cell morphogenesis |
| regulation of secretion by cell |
| regulation of secretion |
| cellular component morphogenesis |
| carboxylic acid metabolic process |
| regulation of cellular localization |
| regulation of cell development |
| endoplasmic reticulum membrane |
| positive regulation of cell differentiation |
| Golgi apparatus |
| oxoacid metabolic process |
| organic acid metabolic process |
| carbohydrate derivative metabolic process |
| macromolecule catabolic process |
| regulation of anatomical structure morphogenesis |
| organonitrogen compound catabolic process |
| cytoskeleton organization |
| cell-cell signaling |
| cell projection organization |
| positive regulation of cellular component organization |
| positive regulation of developmental process |
| integral component of plasma membrane |
| organonitrogen compound biosynthetic process |
| intracellular transport |
| neurogenesis |
| cell development |
| cellular macromolecule biosynthetic process |
| small molecule metabolic process |
| macromolecule biosynthetic process |
| organic substance catabolic process |
| cellular catabolic process |
| regulation of cell differentiation |
| establishment of localization in cell |
| regulation of transport |
| extracellular region |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8220
- Expression level (log2 read counts): -0.71
Expression Distribution
CSPG5 Expression in NALM6 Cells: -0.71
