CTSV
Gene Information
- Official Symbol: CTSV
- Official Name: cathepsin V
- Aliases and Previous Symbols: N/A
- Entrez ID: 1515
- UniProt: O60911
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Cysteine protease. May have an important role in corneal physiology. {ECO:0000269|PubMed:10029531, ECO:0000269|PubMed:9727401}.
Pfam Domains GO Terms
Pfam Domains
| Inhibitor I29 |
| Peptidase C1 |
GO Terms
| kininogen binding |
| response to odorant |
| autophagic cell death |
| Sertoli cell differentiation |
| decidualization |
| response to gonadotropin |
| aminopeptidase activity |
| cysteine-type peptidase activity |
| maternal placenta development |
| multicellular organism aging |
| regulation of keratinocyte differentiation |
| peptide binding |
| regulation of epidermal cell differentiation |
| microvillus |
| maternal process involved in female pregnancy |
| extracellular matrix disassembly |
| apical part of cell |
| nerve development |
| regulation of epidermis development |
| secretory granule |
| cysteine-type endopeptidase activity |
| lysosomal lumen |
| antigen processing and presentation of exogenous peptide antigen via MHC class II |
| antigen processing and presentation of peptide or polysaccharide antigen via MHC class II |
| antigen processing and presentation of peptide antigen via MHC class II |
| male gonad development |
| perikaryon |
| development of primary male sexual characteristics |
| response to glucose |
| regulation of epithelial cell differentiation |
| response to hexose |
| response to glucocorticoid |
| response to monosaccharide |
| cellular response to starvation |
| placenta development |
| male sex differentiation |
| response to corticosteroid |
| response to carbohydrate |
| antigen processing and presentation of exogenous peptide antigen |
| female pregnancy |
| antigen processing and presentation of exogenous antigen |
| antigen processing and presentation of peptide antigen |
| response to starvation |
| gonad development |
| multi-multicellular organism process |
| antigen processing and presentation |
| development of primary sexual characteristics |
| cellular response to nutrient levels |
| lysosome |
| cellular response to extracellular stimulus |
| sex differentiation |
| protein-containing complex binding |
| aging |
| neuron projection |
| response to steroid hormone |
| cellular response to external stimulus |
| extracellular matrix organization |
| extracellular structure organization |
| external side of plasma membrane |
| cellular component disassembly |
| reproductive structure development |
| reproductive system development |
| response to nutrient levels |
| response to extracellular stimulus |
| spermatogenesis |
| male gamete generation |
| proteolysis involved in cellular protein catabolic process |
| cellular protein catabolic process |
| developmental process involved in reproduction |
| epithelial cell differentiation |
| protein catabolic process |
| gamete generation |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| response to lipid |
| cellular macromolecule catabolic process |
| response to hormone |
| response to organic cyclic compound |
| multi-organism reproductive process |
| macromolecule catabolic process |
| programmed cell death |
| organonitrogen compound catabolic process |
| cell death |
| epithelium development |
| proteolysis |
| reproductive process |
| reproduction |
| response to endogenous stimulus |
| response to oxygen-containing compound |
| extracellular space |
| cellular response to stress |
| tissue development |
| organic substance catabolic process |
| cellular catabolic process |
| regulation of cell differentiation |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Ribavirin 10μM R01 exp52 | -2.63 |
| Mubritinib 0.2μM R01 exp48 | -2.18 |
| FK-506 5μM R07 exp358 | -2.03 |
| Golgicide-A 4μM R03 exp122 | 1.7 |
| Myriocin 25μM R06 exp293 | 1.86 |
| ABT-702 5μM R06 exp261 | 2.15 |
| Wortmannin 0.5μM R00 exp37 | 2.51 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10308
- Expression level (log2 read counts): 3.34
Expression Distribution
CTSV Expression in NALM6 Cells: 3.34
