DAXX
Gene Information
- Official Symbol: DAXX
- Official Name: death domain associated protein
- Aliases and Previous Symbols: N/A
- Entrez ID: 1616
- UniProt: Q9UER7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Daxx |
GO Terms
| cellular response to diamide |
| response to diamide |
| cellular response to sodium arsenite |
| response to sodium arsenite |
| cellular response to salt |
| SUMO binding |
| response to herbicide |
| response to insecticide |
| cellular response to arsenic-containing substance |
| response to salt |
| protein kinase activator activity |
| cellular response to copper ion |
| response to arsenic-containing substance |
| extrinsic apoptotic signaling pathway via death domain receptors |
| androgen receptor signaling pathway |
| cellular response to cadmium ion |
| activation of JUN kinase activity |
| androgen receptor binding |
| response to copper ion |
| chromosome, centromeric region |
| heat shock protein binding |
| response to cadmium ion |
| p53 binding |
| intracellular steroid hormone receptor signaling pathway |
| cellular response to heat |
| positive regulation of JUN kinase activity |
| JNK cascade |
| regulation of JUN kinase activity |
| positive regulation of neuron death |
| response to antineoplastic agent |
| extrinsic apoptotic signaling pathway |
| PML body |
| stress-activated MAPK cascade |
| protein N-terminus binding |
| response to heat |
| nucleosome assembly |
| cellular response to antibiotic |
| steroid hormone mediated signaling pathway |
| cellular response to unfolded protein |
| histone binding |
| chromatin assembly |
| positive regulation of JNK cascade |
| stress-activated protein kinase signaling cascade |
| cellular response to topologically incorrect protein |
| activation of MAPK activity |
| chromatin assembly or disassembly |
| nucleosome organization |
| chromatin remodeling |
| response to unfolded protein |
| intracellular receptor signaling pathway |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| hormone-mediated signaling pathway |
| response to temperature stimulus |
| DNA packaging |
| regulation of JNK cascade |
| response to topologically incorrect protein |
| cellular response to steroid hormone stimulus |
| cellular response to metal ion |
| regulation of protein ubiquitination |
| protein-DNA complex assembly |
| cellular response to toxic substance |
| cellular response to inorganic substance |
| regulation of protein modification by small protein conjugation or removal |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| transcription corepressor activity |
| protein-DNA complex subunit organization |
| positive regulation of MAP kinase activity |
| nuclear body |
| apoptotic signaling pathway |
| transcription coactivator activity |
| ubiquitin protein ligase binding |
| DNA conformation change |
| response to antibiotic |
| regulation of neuron death |
| response to steroid hormone |
| activation of protein kinase activity |
| transcription factor binding |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| enzyme binding |
| response to metal ion |
| MAPK cascade |
| signal transduction by protein phosphorylation |
| cellular response to drug |
| protein kinase binding |
| protein heterodimerization activity |
| response to toxic substance |
| regulation of protein serine/threonine kinase activity |
| cellular response to lipid |
| response to inorganic substance |
| positive regulation of protein kinase activity |
| cellular response to organic cyclic compound |
| positive regulation of MAPK cascade |
| positive regulation of kinase activity |
| cellular response to hormone stimulus |
| positive regulation of transferase activity |
| cellular response to nitrogen compound |
| positive regulation of cell death |
| chromatin organization |
| viral process |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| symbiotic process |
| regulation of protein kinase activity |
| interspecies interaction between organisms |
| cellular protein-containing complex assembly |
| response to lipid |
| nucleolus |
| regulation of kinase activity |
| response to hormone |
| response to organic cyclic compound |
| apoptotic process |
| protein phosphorylation |
| regulation of transferase activity |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| response to drug |
| programmed cell death |
| positive regulation of phosphorylation |
| chromosome organization |
| response to nitrogen compound |
| cell death |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| response to abiotic stimulus |
| negative regulation of transcription, DNA-templated |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| phosphorylation |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| protein-containing complex assembly |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Aphidicolin 0.4μM R08 exp440 | -2.26 |
| Apcin 50 to 100μM on day4 R04 exp176 | -2.22 |
| Resveratrol 16μM R03 exp147 | -1.95 |
| Pyridostatin 4μM R05 exp240 | -1.87 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 3/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 1/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 1037
- Expression level (log2 read counts): 6.43
Expression Distribution
DAXX Expression in NALM6 Cells: 6.43
