DDX42
Gene Information
- Official Symbol: DDX42
- Official Name: DEAD-box helicase 42
- Aliases and Previous Symbols: N/A
- Entrez ID: 11325
- UniProt: Q86XP3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: ATP-dependent RNA helicase. Binds to partially double- stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm. {ECO:0000269|PubMed:16397294, ECO:0000269|PubMed:19377511}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 1984
- Expression level (log2 read counts): 8.1
DDX42 Expression in NALM6 Cells: 8.1
