EFNA1
Gene Information
- Official Symbol: EFNA1
- Official Name: ephrin A1
- Aliases and Previous Symbols: N/A
- Entrez ID: 1942
- UniProt: P20827
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis. {ECO:0000269|PubMed:17332925, ECO:0000269|PubMed:18794797}.
Pfam Domains GO Terms
Pfam Domains
| Ephrin |
GO Terms
| endocardial cushion to mesenchymal transition involved in heart valve formation |
| notochord formation |
| endocardial cushion to mesenchymal transition |
| negative regulation of dendritic spine morphogenesis |
| positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process |
| negative regulation of thymocyte apoptotic process |
| positive regulation of aspartic-type peptidase activity |
| regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process |
| mitral valve morphogenesis |
| notochord morphogenesis |
| regulation of aspartic-type peptidase activity |
| mitral valve development |
| regulation of thymocyte apoptotic process |
| heart valve formation |
| negative regulation of dendritic spine development |
| positive regulation of amyloid-beta formation |
| negative regulation of dendrite morphogenesis |
| negative regulation of T cell apoptotic process |
| positive regulation of amyloid precursor protein catabolic process |
| notochord development |
| atrioventricular valve morphogenesis |
| negative regulation of synapse organization |
| atrioventricular valve development |
| negative regulation of epithelial to mesenchymal transition |
| regulation of amyloid-beta formation |
| aortic valve morphogenesis |
| negative regulation of lymphocyte apoptotic process |
| ephrin receptor binding |
| cardiac epithelial to mesenchymal transition |
| negative regulation of dendrite development |
| aortic valve development |
| anchored component of plasma membrane |
| regulation of T cell apoptotic process |
| regulation of amyloid precursor protein catabolic process |
| semi-lunar valve development |
| regulation of dendritic spine morphogenesis |
| regulation of cell adhesion mediated by integrin |
| negative regulation of leukocyte apoptotic process |
| heart valve morphogenesis |
| substrate adhesion-dependent cell spreading |
| regulation of lymphocyte apoptotic process |
| positive regulation of protein tyrosine kinase activity |
| heart valve development |
| epithelial to mesenchymal transition |
| negative regulation of proteolysis involved in cellular protein catabolic process |
| regulation of dendritic spine development |
| regulation of leukocyte apoptotic process |
| regulation of epithelial to mesenchymal transition |
| negative regulation of cellular protein catabolic process |
| ephrin receptor signaling pathway |
| regulation of protein tyrosine kinase activity |
| regulation of blood vessel endothelial cell migration |
| regulation of dendrite morphogenesis |
| regulation of postsynapse organization |
| negative regulation of cell morphogenesis involved in differentiation |
| negative regulation of protein catabolic process |
| regulation of dendrite development |
| positive regulation of cellular amide metabolic process |
| negative regulation of neuron projection development |
| mesenchymal cell differentiation |
| regulation of endothelial cell migration |
| negative regulation of MAPK cascade |
| positive regulation of endopeptidase activity |
| protein stabilization |
| negative regulation of cell projection organization |
| cell-substrate adhesion |
| regulation of axonogenesis |
| positive regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of peptidase activity |
| regulation of proteolysis involved in cellular protein catabolic process |
| regulation of synapse organization |
| regulation of epithelial cell migration |
| mesenchyme development |
| negative regulation of neuron differentiation |
| regulation of synapse structure or activity |
| regulation of cellular protein catabolic process |
| heart morphogenesis |
| negative regulation of cellular catabolic process |
| regulation of peptidyl-tyrosine phosphorylation |
| axon guidance |
| neuron projection guidance |
| regulation of angiogenesis |
| regulation of protein stability |
| embryonic organ morphogenesis |
| negative regulation of neurogenesis |
| regulation of cell morphogenesis involved in differentiation |
| negative regulation of catabolic process |
| negative regulation of nervous system development |
| angiogenesis |
| regulation of vasculature development |
| negative regulation of cell development |
| signaling receptor binding |
| negative regulation of proteolysis |
| positive regulation of proteolysis |
| axonogenesis |
| regulation of protein catabolic process |
| regulation of cellular amide metabolic process |
| negative regulation of protein phosphorylation |
| blood vessel morphogenesis |
| axon development |
| regulation of endopeptidase activity |
| cell morphogenesis involved in neuron differentiation |
| embryonic organ development |
| negative regulation of phosphorylation |
| regulation of peptidase activity |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| blood vessel development |
| regulation of cell morphogenesis |
| cell projection morphogenesis |
| regulation of neuron projection development |
| negative regulation of intracellular signal transduction |
| vasculature development |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| cell part morphogenesis |
| cardiovascular system development |
| heart development |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| chemotaxis |
| taxis |
| cell morphogenesis involved in differentiation |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| embryonic morphogenesis |
| positive regulation of kinase activity |
| negative regulation of protein modification process |
| tube morphogenesis |
| positive regulation of transferase activity |
| regulation of neuron differentiation |
| neuron projection development |
| regulation of cell adhesion |
| regulation of plasma membrane bounded cell projection organization |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| enzyme linked receptor protein signaling pathway |
| cell morphogenesis |
| regulation of proteolysis |
| regulation of MAPK cascade |
| positive regulation of hydrolase activity |
| regulation of protein kinase activity |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| regulation of cellular catabolic process |
| tube development |
| regulation of cell migration |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| regulation of cell motility |
| regulation of nervous system development |
| cell adhesion |
| regulation of cell development |
| biological adhesion |
| negative regulation of developmental process |
| animal organ morphogenesis |
| cell migration |
| regulation of transferase activity |
| embryo development |
| regulation of locomotion |
| regulation of cellular component movement |
| regulation of catabolic process |
| negative regulation of cell death |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| negative regulation of cellular protein metabolic process |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| cell motility |
| localization of cell |
| negative regulation of protein metabolic process |
| cell-cell signaling |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| cell projection organization |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| locomotion |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| negative regulation of cellular macromolecule biosynthetic process |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| neurogenesis |
| cell development |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Golgicide-A 4μM R03 exp122 | 1.73 |
| 2-Methoxyestradiol 0.2μM R01 exp40 | 1.74 |
| Nifuroxazide 1μM R01 exp51 | 1.81 |
| Docetaxel 0.002μM R01 exp45 | 2.06 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.506 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4371
- Expression level (log2 read counts): -0.39
Expression Distribution
EFNA1 Expression in NALM6 Cells: -0.39
