EIF2B3

Entrez Summary: The protein encoded by this gene is one of the subunits of initiation factor eIF2B, which catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP. It has also been found to function as a cofactor of hepatitis C virus internal ribosome entry site-mediated translation. Mutations in this gene have been associated with leukodystrophy with vanishing white matter. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
UniProt Summary: Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
MK2206 4μM R08 exp504	-1.84
FBS-Wisent 0.1 R07 exp426	1.71
Centrinone 0.5μM R07 exp343	1.75
Dexamethasone 0.006 to 0.015μM on day4 R07 exp352	1.76
Torin1 0.08μM R02 exp82	1.79
CHIR-124 0.04μM R06 exp272	1.84
SNS-032 25μM R07 exp401	2.15
Olaparib 4μM R08 exp512	2.25

Gene	Correlation
HARS	0.648
ALG5	0.401

Global Fraction of Cell Lines Where Essential: 686/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	27/28
blood	25/28
bone	24/26
breast	31/33
central nervous system	53/56
cervix	3/4
colorectal	16/17
esophagus	12/13
fibroblast	1/1
gastric	16/16
kidney	21/21
liver	17/20
lung	69/75
lymphocyte	15/16
ovary	23/26
pancreas	22/24
peripheral nervous system	15/16
plasma cell	13/15
prostate	1/1
skin	22/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	18/22
urinary tract	27/29
uterus	4/5

Expression Distribution