ELL3
Gene Information
- Official Symbol: ELL3
- Official Name: elongation factor for RNA polymerase II 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 80237
- UniProt: Q9HB65
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Occludin ELL |
| ELL |
GO Terms
| enhancer binding |
| negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator |
| negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator |
| transcription elongation factor complex |
| regulation of intrinsic apoptotic signaling pathway by p53 class mediator |
| positive regulation of DNA-templated transcription, elongation |
| negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| negative regulation of signal transduction by p53 class mediator |
| regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| regulation of DNA-templated transcription, elongation |
| positive regulation of neural precursor cell proliferation |
| snRNA transcription by RNA polymerase II |
| snRNA transcription |
| transcription elongation from RNA polymerase II promoter |
| negative regulation of response to DNA damage stimulus |
| regulation of epithelial to mesenchymal transition |
| regulation of neural precursor cell proliferation |
| DNA-templated transcription, elongation |
| ncRNA transcription |
| negative regulation of intrinsic apoptotic signaling pathway |
| stem cell differentiation |
| regulation of intrinsic apoptotic signaling pathway |
| regulation of signal transduction by p53 class mediator |
| regulation of response to DNA damage stimulus |
| negative regulation of apoptotic signaling pathway |
| regulation of apoptotic signaling pathway |
| positive regulation of neurogenesis |
| transcription by RNA polymerase II |
| negative regulation of intracellular signal transduction |
| positive regulation of nervous system development |
| positive regulation of cell development |
| spermatogenesis |
| male gamete generation |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| RNA biosynthetic process |
| gamete generation |
| regulation of cellular response to stress |
| regulation of neurogenesis |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| nucleolus |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| positive regulation of cell population proliferation |
| regulation of nervous system development |
| regulation of cell development |
| positive regulation of cell differentiation |
| negative regulation of cell death |
| multi-organism reproductive process |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of signal transduction |
| organic cyclic compound biosynthetic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| reproductive process |
| reproduction |
| regulation of response to stress |
| generation of neurons |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| regulation of programmed cell death |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| RNA metabolic process |
| regulation of cell death |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| macromolecule biosynthetic process |
| regulation of cell differentiation |
| regulation of intracellular signal transduction |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Actinomycin-D 0.01μM R00 exp4 | -1.93 |
| Nifuroxazide 1μM R01 exp51 | -1.81 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3722
- Expression level (log2 read counts): 3.4
Expression Distribution
ELL3 Expression in NALM6 Cells: 3.4
