FADS1
Gene Information
- Official Symbol: FADS1
- Official Name: fatty acid desaturase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 3992
- UniProt: O60427
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| FA desaturase |
| Cyt-b5 |
GO Terms
| acyl-CoA delta5-desaturase activity |
| omega-6 fatty acid desaturase activity |
| C-5 sterol desaturase activity |
| alpha-linolenic acid metabolic process |
| linoleic acid metabolic process |
| unsaturated fatty acid biosynthetic process |
| icosanoid biosynthetic process |
| fatty acid derivative biosynthetic process |
| unsaturated fatty acid metabolic process |
| icosanoid metabolic process |
| long-chain fatty acid metabolic process |
| fatty acid biosynthetic process |
| oxidoreductase activity |
| cellular response to starvation |
| fatty acid derivative metabolic process |
| monocarboxylic acid biosynthetic process |
| response to starvation |
| cellular response to nutrient levels |
| phospholipid biosynthetic process |
| cellular response to extracellular stimulus |
| carboxylic acid biosynthetic process |
| organic acid biosynthetic process |
| fatty acid metabolic process |
| cellular response to external stimulus |
| phospholipid metabolic process |
| regulation of lipid metabolic process |
| response to nutrient levels |
| drug metabolic process |
| monocarboxylic acid metabolic process |
| response to extracellular stimulus |
| organophosphate biosynthetic process |
| lipid biosynthetic process |
| small molecule biosynthetic process |
| intracellular membrane-bounded organelle |
| organophosphate metabolic process |
| carboxylic acid metabolic process |
| endoplasmic reticulum membrane |
| cellular lipid metabolic process |
| oxidation-reduction process |
| oxoacid metabolic process |
| organic acid metabolic process |
| cell-cell signaling |
| lipid metabolic process |
| mitochondrion |
| cellular response to stress |
| small molecule metabolic process |
| regulation of cell differentiation |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| ∆-9-Tetrahydrocannabinol 30μM R08 exp445 | -2.03 |
| Quercetin 20μM R08 exp517 | 1.79 |
| Dynasore 10μM R04 exp180 | 1.83 |
| Dynasore 7μM R08 exp436 | 2.06 |
| Tubacin 1.6μM R07 exp416 | 6.36 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8838
- Expression level (log2 read counts): 7.18
Expression Distribution
FADS1 Expression in NALM6 Cells: 7.18
