FLOT2
Gene Information
- Official Symbol: FLOT2
- Official Name: flotillin 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 2319
- UniProt: Q14254
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.
Pfam Domains GO Terms
Pfam Domains
| Band 7 |
GO Terms
| positive regulation of establishment of T cell polarity |
| protein localization to plasma membrane raft |
| anchored component of presynaptic active zone membrane |
| regulation of establishment of T cell polarity |
| anterograde dendritic transport |
| flotillin complex |
| protein localization to membrane raft |
| dendritic transport |
| regulation of toll-like receptor 3 signaling pathway |
| membrane raft assembly |
| uropod |
| negative regulation of amyloid precursor protein catabolic process |
| acrosomal membrane |
| membrane raft organization |
| regulation of establishment of cell polarity |
| cell-cell contact zone |
| regulation of establishment or maintenance of cell polarity |
| regulation of heterotypic cell-cell adhesion |
| dendrite cytoplasm |
| ionotropic glutamate receptor binding |
| regulation of amyloid precursor protein catabolic process |
| membrane assembly |
| membrane biogenesis |
| regulation of postsynaptic membrane neurotransmitter receptor levels |
| cortical actin cytoskeleton |
| regulation of myoblast differentiation |
| endocytic vesicle |
| axo-dendritic transport |
| regulation of toll-like receptor signaling pathway |
| caveola |
| protease binding |
| cell-cell adherens junction |
| vesicle |
| positive regulation of NF-kappaB transcription factor activity |
| transport along microtubule |
| cytoskeleton-dependent intracellular transport |
| protein stabilization |
| lamellipodium |
| microtubule-based transport |
| protein localization to plasma membrane |
| basolateral plasma membrane |
| positive regulation of T cell activation |
| positive regulation of leukocyte cell-cell adhesion |
| protein localization to cell periphery |
| cytoplasmic vesicle |
| positive regulation of cell-cell adhesion |
| positive regulation of DNA-binding transcription factor activity |
| endosome |
| microtubule-based movement |
| regulation of protein stability |
| regulation of leukocyte cell-cell adhesion |
| regulation of T cell activation |
| apical plasma membrane |
| glutamatergic synapse |
| positive regulation of lymphocyte activation |
| regulation of cell-cell adhesion |
| positive regulation of leukocyte activation |
| positive regulation of cell adhesion |
| epidermis development |
| focal adhesion |
| positive regulation of cell activation |
| regulation of DNA-binding transcription factor activity |
| regulation of innate immune response |
| protein localization to membrane |
| protein heterodimerization activity |
| regulation of lymphocyte activation |
| regulation of response to biotic stimulus |
| regulation of leukocyte activation |
| regulation of cell activation |
| microtubule-based process |
| regulation of cell adhesion |
| perinuclear region of cytoplasm |
| regulation of defense response |
| regulation of multi-organism process |
| membrane organization |
| cell adhesion |
| biological adhesion |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| regulation of immune response |
| positive regulation of immune system process |
| regulation of response to stress |
| intracellular transport |
| movement of cell or subcellular component |
| cellular protein localization |
| cellular macromolecule localization |
| regulation of immune system process |
| negative regulation of gene expression |
| tissue development |
| positive regulation of molecular function |
| regulation of cell differentiation |
| establishment of localization in cell |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| THZ531 0.225μM R08 exp444 | -1.91 |
| UM0011500 10μM R05 exp246 | -1.91 |
| Rotenone 2μM R00 exp33 | -1.71 |
| IWR1 50μM R08 exp495 | 1.8 |
| UM131593 0.2μM R03 exp106 | 1.8 |
| UM0125461 0.74μM R02 exp84 | 1.83 |
| 2-Methoxyestradiol 0.2μM R01 exp40 | 2.11 |
| Nutlin-3A 1.6μM R06 exp294 | 2.17 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7584
- Expression level (log2 read counts): 4.93
Expression Distribution
FLOT2 Expression in NALM6 Cells: 4.93
