FXYD5
Gene Information
- Official Symbol: FXYD5
- Official Name: FXYD domain containing ion transport regulator 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 53827
- UniProt: Q96DB9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009].
- UniProt Summary: Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis. {ECO:0000269|PubMed:11756660}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 9589
- Expression level (log2 read counts): 5.43
FXYD5 Expression in NALM6 Cells: 5.43
