GADD45A

Gene Information

Official Symbol: GADD45A
Official Name: growth arrest and DNA damage inducible alpha
Aliases and Previous Symbols: N/A
Entrez ID: 1647
UniProt: P24522
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity (By similarity). Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. {ECO:0000250}.

Pfam Domains GO Terms

Pfam Domains

Ribosomal L7Ae

GO Terms

activation of MAPKKK activity

mitotic cell cycle arrest

positive regulation of p38MAPK cascade

RNA polymerase II core promoter sequence-specific DNA binding

regulation of p38MAPK cascade

DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest

signal transduction involved in mitotic DNA damage checkpoint

signal transduction involved in mitotic cell cycle checkpoint

signal transduction involved in mitotic G1 DNA damage checkpoint

intracellular signal transduction involved in G1 DNA damage checkpoint

signal transduction involved in mitotic DNA integrity checkpoint

mitotic G1 DNA damage checkpoint

mitotic G1/S transition checkpoint

G1 DNA damage checkpoint

cellular response to ionizing radiation

signal transduction involved in DNA integrity checkpoint

signal transduction involved in DNA damage checkpoint

signal transduction involved in cell cycle checkpoint

DNA damage response, signal transduction by p53 class mediator

cellular response to mechanical stimulus

positive regulation of cell cycle arrest

centrosome cycle

microtubule organizing center organization

kinase binding

mitotic DNA damage checkpoint

positive regulation of reactive oxygen species metabolic process

regulation of cyclin-dependent protein serine/threonine kinase activity

regulation of cyclin-dependent protein kinase activity

negative regulation of G1/S transition of mitotic cell cycle

mitotic DNA integrity checkpoint

signal transduction in response to DNA damage

negative regulation of cell cycle G1/S phase transition

protein N-terminus binding

regulation of cell cycle arrest

signal transduction by p53 class mediator

DNA damage checkpoint

positive regulation of JNK cascade

DNA integrity checkpoint

cell cycle arrest

response to ionizing radiation

regulation of G1/S transition of mitotic cell cycle

mitotic cell cycle checkpoint

regulation of cell cycle G1/S phase transition

positive regulation of stress-activated MAPK cascade

positive regulation of stress-activated protein kinase signaling cascade

cellular response to radiation

regulation of reactive oxygen species metabolic process

regulation of JNK cascade

cell cycle checkpoint

negative regulation of mitotic cell cycle phase transition

response to mechanical stimulus

negative regulation of protein kinase activity

negative regulation of cell cycle phase transition

regulation of stress-activated MAPK cascade

regulation of stress-activated protein kinase signaling cascade

negative regulation of kinase activity

positive regulation of MAP kinase activity

negative regulation of transferase activity

positive regulation of cell cycle process

negative regulation of mitotic cell cycle

cellular response to abiotic stimulus

cellular response to environmental stimulus

negative regulation of cell cycle process

activation of protein kinase activity

cellular response to external stimulus

positive regulation of protein serine/threonine kinase activity

regulation of MAP kinase activity

positive regulation of cell cycle

nuclear speck

negative regulation of protein phosphorylation

regulation of mitotic cell cycle phase transition

response to radiation

negative regulation of phosphorylation

regulation of cell cycle phase transition

microtubule cytoskeleton organization

protein heterodimerization activity

DNA repair

regulation of protein serine/threonine kinase activity

positive regulation of protein kinase activity

positive regulation of MAPK cascade

negative regulation of phosphate metabolic process

negative regulation of phosphorus metabolic process

negative regulation of cell cycle

positive regulation of kinase activity

negative regulation of protein modification process

mitotic cell cycle process

regulation of mitotic cell cycle

positive regulation of apoptotic process

positive regulation of programmed cell death

positive regulation of transferase activity

microtubule-based process

mitotic cell cycle

positive regulation of cell death

regulation of cellular response to stress

DNA metabolic process

regulation of MAPK cascade

regulation of cell cycle process

cellular response to DNA damage stimulus

negative regulation of catalytic activity

regulation of protein kinase activity

regulation of kinase activity

protein homodimerization activity

apoptotic process

regulation of transferase activity

cell cycle process

positive regulation of protein phosphorylation

positive regulation of intracellular signal transduction

negative regulation of cellular protein metabolic process

programmed cell death

positive regulation of phosphorylation

cell death

negative regulation of protein metabolic process

cytoskeleton organization

positive regulation of phosphate metabolic process

positive regulation of phosphorus metabolic process

negative regulation of molecular function

response to abiotic stimulus

regulation of cell cycle

positive regulation of protein modification process

cell cycle

positive regulation of catalytic activity

regulation of protein phosphorylation

regulation of response to stress

regulation of apoptotic process

regulation of programmed cell death

regulation of phosphorylation

positive regulation of cellular protein metabolic process

positive regulation of signal transduction

regulation of cell death

intracellular signal transduction

cellular response to stress

positive regulation of protein metabolic process

positive regulation of molecular function

regulation of phosphate metabolic process

regulation of phosphorus metabolic process

positive regulation of cell communication

positive regulation of signaling

regulation of intracellular signal transduction

regulation of protein modification process

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Compound Hit

Screen	Score
Hypoxia 5%O2 R04 exp191	-2.08
Rapamycin 10μM R00 exp30	-1.9
Rapamycin 1μM R00 exp29	-1.87
BI-6727 0.001μM R01 exp42	-1.8
Wortmannin 5μM R00 exp38	-1.77

Most Correlated Genes in Chemogenomics

No correlation found to any other genes in chemogenomics.

Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15379
Expression level (log2 read counts): 4.31

Expression Distribution