HMGCS1
Gene Information
- Official Symbol: HMGCS1
- Official Name: 3-hydroxy-3-methylglutaryl-CoA synthase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 3157
- UniProt: Q01581
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
Pfam Domains GO Terms
Pfam Domains
| HMG CoA synt C |
| HMG CoA synt N |
GO Terms
| response to low light intensity stimulus |
| response to tellurium ion |
| isoprenoid biosynthetic process via mevalonate |
| hydroxymethylglutaryl-CoA synthase activity |
| farnesyl diphosphate biosynthetic process, mevalonate pathway |
| farnesyl diphosphate biosynthetic process |
| farnesyl diphosphate metabolic process |
| organic acid binding |
| cellular response to follicle-stimulating hormone stimulus |
| response to vitamin E |
| response to light intensity |
| isomerase activity |
| terpenoid biosynthetic process |
| response to follicle-stimulating hormone |
| cellular response to cholesterol |
| cellular response to gonadotropin stimulus |
| cellular response to low-density lipoprotein particle stimulus |
| cellular response to sterol |
| response to cholesterol |
| response to lipoprotein particle |
| isoprenoid biosynthetic process |
| response to gonadotropin |
| cellular response to lipoprotein particle stimulus |
| response to sterol |
| acetyl-CoA metabolic process |
| cholesterol biosynthetic process |
| regulation of cholesterol biosynthetic process |
| secondary alcohol biosynthetic process |
| regulation of sterol biosynthetic process |
| sterol biosynthetic process |
| regulation of cholesterol metabolic process |
| drug binding |
| regulation of alcohol biosynthetic process |
| cellular response to alcohol |
| response to vitamin |
| regulation of steroid biosynthetic process |
| acyl-CoA metabolic process |
| thioester metabolic process |
| alcohol biosynthetic process |
| regulation of steroid metabolic process |
| cholesterol metabolic process |
| terpenoid metabolic process |
| liver development |
| steroid biosynthetic process |
| hepaticobiliary system development |
| secondary alcohol metabolic process |
| ribonucleoside bisphosphate metabolic process |
| nucleoside bisphosphate metabolic process |
| purine nucleoside bisphosphate metabolic process |
| male gonad development |
| sterol metabolic process |
| development of primary male sexual characteristics |
| isoprenoid metabolic process |
| response to purine-containing compound |
| male sex differentiation |
| organic hydroxy compound biosynthetic process |
| regulation of lipid biosynthetic process |
| gonad development |
| response to nutrient |
| development of primary sexual characteristics |
| response to alcohol |
| phospholipid biosynthetic process |
| coenzyme metabolic process |
| steroid metabolic process |
| sex differentiation |
| response to light stimulus |
| purine ribonucleotide metabolic process |
| alcohol metabolic process |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| sulfur compound metabolic process |
| purine-containing compound metabolic process |
| phospholipid metabolic process |
| regulation of lipid metabolic process |
| gland development |
| reproductive structure development |
| regulation of small molecule metabolic process |
| reproductive system development |
| cofactor metabolic process |
| response to radiation |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| organic hydroxy compound metabolic process |
| response to nutrient levels |
| cellular response to lipid |
| response to extracellular stimulus |
| response to inorganic substance |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| cellular response to organic cyclic compound |
| lipid biosynthetic process |
| small molecule biosynthetic process |
| cellular response to hormone stimulus |
| developmental process involved in reproduction |
| brain development |
| head development |
| cellular amide metabolic process |
| response to lipid |
| protein homodimerization activity |
| organophosphate metabolic process |
| response to hormone |
| response to organic cyclic compound |
| cellular lipid metabolic process |
| central nervous system development |
| response to organonitrogen compound |
| response to drug |
| carbohydrate derivative metabolic process |
| cellular response to oxygen-containing compound |
| response to nitrogen compound |
| response to abiotic stimulus |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| organic cyclic compound biosynthetic process |
| reproductive process |
| reproduction |
| response to endogenous stimulus |
| response to oxygen-containing compound |
| small molecule metabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| iCRT14 30μM R08 exp492 | -2.24 |
| AICAR 240μM R05 exp211 | -2.21 |
| QNZ 0.01μM R05 exp241 | -2.02 |
| Resveratrol 16μM R03 exp147 | -1.96 |
| Fluvastatin 2.2μM R06 exp282 | -1.92 |
| Docetaxel 0.001 to 0.002μM on day4 R04 exp159 | 1.71 |
| RO-3306 3 to 4μM on day4 R04 exp165 | 1.98 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| HGC6.3 | 0.682 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 487/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 1/1 |
| bile duct | 23/28 |
| blood | 26/28 |
| bone | 14/26 |
| breast | 24/33 |
| central nervous system | 22/56 |
| cervix | 3/4 |
| colorectal | 11/17 |
| esophagus | 3/13 |
| fibroblast | 0/1 |
| gastric | 13/16 |
| kidney | 17/21 |
| liver | 13/20 |
| lung | 45/75 |
| lymphocyte | 12/16 |
| ovary | 15/26 |
| pancreas | 15/24 |
| peripheral nervous system | 12/16 |
| plasma cell | 10/15 |
| prostate | 1/1 |
| skin | 22/24 |
| soft tissue | 8/9 |
| thyroid | 1/2 |
| upper aerodigestive | 10/22 |
| urinary tract | 15/29 |
| uterus | 3/5 |
Essentiality in NALM6
- Essentiality Rank: 687
- Expression level (log2 read counts): 7.93
Expression Distribution
HMGCS1 Expression in NALM6 Cells: 7.93
