KCNV2
Gene Information
- Official Symbol: KCNV2
- Official Name: potassium voltage-gated channel modifier subfamily V member 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 169522
- UniProt: Q8TDN2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This member is identified as a 'silent subunit', and it does not form homomultimers, but forms heteromultimers with several other subfamily members. Through obligatory heteromerization, it exerts a function-altering effect on other potassium channel subunits. This protein is strongly expressed in pancreas and has a weaker expression in several other tissues. [provided by RefSeq, Jul 2008].
- UniProt Summary: Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 5715
- Expression level (log2 read counts): -2.01
KCNV2 Expression in NALM6 Cells: -2.01
