Pfam Domains GO Terms
| DUF3651 |
| negative regulation of immature T cell proliferation in thymus |
| negative regulation of immature T cell proliferation |
| regulation of immature T cell proliferation in thymus |
| negative regulation of T cell differentiation in thymus |
| regulation of immature T cell proliferation |
| regulation of T cell differentiation in thymus |
| negative regulation of T cell differentiation |
| negative regulation of lymphocyte differentiation |
| negative regulation of T cell proliferation |
| negative regulation of mononuclear cell proliferation |
| negative regulation of lymphocyte proliferation |
| negative regulation of leukocyte proliferation |
| negative regulation of leukocyte differentiation |
| negative regulation of T cell activation |
| negative regulation of leukocyte cell-cell adhesion |
| negative regulation of hemopoiesis |
| regulation of T cell differentiation |
| negative regulation of lymphocyte activation |
| regulation of T cell proliferation |
| regulation of lymphocyte differentiation |
| negative regulation of cell-cell adhesion |
| negative regulation of leukocyte activation |
| negative regulation of canonical Wnt signaling pathway |
| negative regulation of cell activation |
| regulation of lymphocyte proliferation |
| negative regulation of Wnt signaling pathway |
| regulation of mononuclear cell proliferation |
| regulation of leukocyte proliferation |
| regulation of leukocyte differentiation |
| negative regulation of cell adhesion |
| regulation of canonical Wnt signaling pathway |
| regulation of leukocyte cell-cell adhesion |
| regulation of T cell activation |
| Wnt signaling pathway |
| cell-cell signaling by wnt |
| regulation of Wnt signaling pathway |
| regulation of cell-cell adhesion |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| negative regulation of immune system process |
| regulation of hemopoiesis |
| regulation of lymphocyte activation |
| regulation of leukocyte activation |
| regulation of cell activation |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| negative regulation of cell differentiation |
| negative regulation of developmental process |
| endoplasmic reticulum |
| cell-cell signaling |
| negative regulation of multicellular organismal process |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| regulation of immune system process |
| regulation of cell differentiation |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| Bortezomib 0.005μM R00 exp6 | -4.45 |
| Golgicide-A 4μM R03 exp122 | -2.97 |
| Aminopterin 0.005μM R07 exp335 | -2.92 |
| Thapsigargin 0.005μM R07 exp407 | -2.67 |
| Tubacin 1.6μM R07 exp416 | -2.52 |
| 3-Bromopyruvate 7μM R04 exp175 | -2.11 |
| Rapamycin 0.001μM R08 exp429 | -1.91 |
| Olaparib 4μM R08 exp512 | -1.87 |
| Q15 2.7μM R02 exp79 | -1.82 |
| Trimetrexate 0.03μM R08 exp535 | 1.76 |
| Citral 50μM R06 exp274 | 1.79 |
| Hypoxia 5%O2 R04 exp191 | 2.12 |
| iCRT14 30μM R08 exp492 | 2.89 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Expression Distribution