MLLT6
Gene Information
- Official Symbol: MLLT6
- Official Name: MLLT6, PHD finger containing
- Aliases and Previous Symbols: N/A
- Entrez ID: 4302
- UniProt: P55198
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| PHD |
GO Terms
| negative regulation of histone H3-K79 methylation |
| renal potassium excretion |
| renal sodium excretion |
| regulation of histone H3-K79 methylation |
| negative regulation of urine volume |
| negative regulation of histone methylation |
| regulation of urine volume |
| nucleosome binding |
| sodium ion homeostasis |
| positive regulation of sodium ion transport |
| negative regulation of histone modification |
| excretion |
| negative regulation of chromatin organization |
| regulation of histone methylation |
| regulation of sodium ion transport |
| renal system process |
| histone binding |
| negative regulation of chromosome organization |
| monovalent inorganic cation homeostasis |
| regulation of histone modification |
| regulation of chromatin organization |
| positive regulation of ion transport |
| regulation of chromosome organization |
| negative regulation of organelle organization |
| regulation of metal ion transport |
| regulation of body fluid levels |
| negative regulation of protein modification process |
| metal ion homeostasis |
| regulation of ion transport |
| negative regulation of cellular component organization |
| cation homeostasis |
| inorganic ion homeostasis |
| ion homeostasis |
| positive regulation of transport |
| negative regulation of cellular protein metabolic process |
| negative regulation of protein metabolic process |
| chemical homeostasis |
| positive regulation of transcription by RNA polymerase II |
| regulation of organelle organization |
| positive regulation of transcription, DNA-templated |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| positive regulation of RNA metabolic process |
| regulation of protein modification process |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| UNC2400 2μM R03 exp156 | 1.76 |
| IU1-47 25μM R04 exp182 | 1.86 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2660
- Expression level (log2 read counts): 7.92
Expression Distribution
MLLT6 Expression in NALM6 Cells: 7.92
