MLXIPL
Gene Information
- Official Symbol: MLXIPL
- Official Name: MLX interacting protein like
- Aliases and Previous Symbols: N/A
- Entrez ID: 51085
- UniProt: Q9NP71
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| HLH |
GO Terms
| carbohydrate response element binding |
| hexose mediated signaling |
| glucose mediated signaling pathway |
| sugar mediated signaling pathway |
| carbohydrate mediated signaling |
| negative regulation of oxidative phosphorylation |
| fatty acid homeostasis |
| positive regulation of fatty acid biosynthetic process |
| positive regulation of glycolytic process |
| negative regulation of cell cycle arrest |
| negative regulation of ATP metabolic process |
| negative regulation of peptidyl-serine phosphorylation |
| regulation of oxidative phosphorylation |
| energy homeostasis |
| positive regulation of fatty acid metabolic process |
| acylglycerol homeostasis |
| triglyceride homeostasis |
| regulation of fatty acid biosynthetic process |
| positive regulation of ATP metabolic process |
| positive regulation of purine nucleotide metabolic process |
| positive regulation of nucleotide metabolic process |
| anion homeostasis |
| cellular response to glucose stimulus |
| cellular response to hexose stimulus |
| cellular response to monosaccharide stimulus |
| positive regulation of carbohydrate metabolic process |
| regulation of glycolytic process |
| positive regulation of lipid biosynthetic process |
| cellular response to carbohydrate stimulus |
| regulation of fatty acid metabolic process |
| cellular glucose homeostasis |
| regulation of carbohydrate catabolic process |
| regulation of cell cycle arrest |
| regulation of purine nucleotide metabolic process |
| regulation of nucleotide metabolic process |
| regulation of ATP metabolic process |
| lipid homeostasis |
| regulation of peptidyl-serine phosphorylation |
| response to glucose |
| positive regulation of small molecule metabolic process |
| positive regulation of lipid metabolic process |
| response to hexose |
| response to monosaccharide |
| regulation of generation of precursor metabolites and energy |
| regulation of cellular ketone metabolic process |
| response to carbohydrate |
| glucose homeostasis |
| carbohydrate homeostasis |
| regulation of lipid biosynthetic process |
| regulation of carbohydrate metabolic process |
| transcription factor complex |
| DNA-binding transcription repressor activity, RNA polymerase II-specific |
| multicellular organismal homeostasis |
| negative regulation of cell cycle process |
| transcription factor binding |
| positive regulation of cellular catabolic process |
| positive regulation of cell cycle |
| regulation of lipid metabolic process |
| negative regulation of protein phosphorylation |
| regulation of small molecule metabolic process |
| positive regulation of catabolic process |
| negative regulation of phosphorylation |
| protein heterodimerization activity |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of cell cycle |
| negative regulation of protein modification process |
| DNA-binding transcription factor activity |
| cellular chemical homeostasis |
| regulation of cell cycle process |
| ion homeostasis |
| regulation of cellular catabolic process |
| negative regulation of transcription by RNA polymerase II |
| protein homodimerization activity |
| cellular homeostasis |
| positive regulation of cell population proliferation |
| regulation of catabolic process |
| negative regulation of cellular protein metabolic process |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| negative regulation of protein metabolic process |
| chemical homeostasis |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of phosphorylation |
| regulation of cell population proliferation |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| intracellular signal transduction |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Nocodazole 0.02μM R00 exp23 | 1.92 |
| Senexin-A 25μM R07 exp400 | 1.98 |
| Chloramphenicol 2μM R00 exp12 | 2.07 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5146
- Expression level (log2 read counts): 2.62
Expression Distribution
MLXIPL Expression in NALM6 Cells: 2.62
