MRPL14

Entrez Summary: N/A
UniProt Summary: Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable). {ECO:0000305|PubMed:22829778}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Vitamin-D3 40μM R08 exp536	-2.13
LJH685 50μM R08 exp433	1.74
Dimethyloxaloylglycine 100μM R05 exp229	1.82
Vemurafenib 6.6μM R02 exp89	1.94
Quercetin 20μM R08 exp517	2.13

Global Fraction of Cell Lines Where Essential: 78/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	4/28
blood	1/28
bone	1/26
breast	8/33
central nervous system	2/56
cervix	0/4
colorectal	4/17
esophagus	2/13
fibroblast	0/1
gastric	1/16
kidney	3/21
liver	3/20
lung	11/75
lymphocyte	1/16
ovary	1/26
pancreas	2/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	3/24
soft tissue	2/9
thyroid	0/2
upper aerodigestive	5/22
urinary tract	1/29
uterus	1/5

Expression Distribution