NAGS
Gene Information
- Official Symbol: N/AGS
- Official Name: N-acetylglutamate synthase
- Aliases and Previous Symbols: N/A
- Entrez ID: 162417
- UniProt: Q8N159
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The N-acetylglutamate synthase gene encodes a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetyl coenzyme-A. NAG is a cofactor of carbamyl phosphate synthetase I (CPSI), the first enzyme of the urea cycle in mammals. This gene may regulate ureagenesis by altering NAG availability and, thereby, CPSI activity. Deficiencies in N-acetylglutamate synthase have been associated with hyperammonemia. [provided by RefSeq, Jul 2008].
- UniProt Summary: Plays a role in the regulation of ureagenesis by producing the essential cofactor N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPSI) activity.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 10982
- Expression level (log2 read counts): -1.33
NAGS Expression in NALM6 Cells: -1.33
