NCAPD2

Entrez Summary: N/A
UniProt Summary: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain. {ECO:0000269|PubMed:11136719}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Aphidicolin 0.4μM R08 exp440	-2.33
LB-100 2μM R05 exp210	-2.17
ONC212 0.15μM R08 exp513	-1.97
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	-1.91
Deguelin 0.05μM R02 exp69	-1.85
ML-792 0.2μM R08 exp505	-1.83
All-trans-Retinoic-Acid 8μM R07 exp333	-1.81
Nutlin-3A 1.6μM R06 exp294	-1.76
DABN racemic mixture R03 exp93	2.21

Global Fraction of Cell Lines Where Essential: 347/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	10/28
blood	21/28
bone	14/25
breast	21/33
central nervous system	20/56
cervix	2/4
colorectal	6/17
esophagus	3/13
fibroblast	1/1
gastric	10/15
kidney	10/21
liver	9/20
lung	36/75
lymphocyte	6/14
ovary	9/26
pancreas	9/24
peripheral nervous system	10/16
plasma cell	9/15
prostate	1/1
skin	10/24
soft tissue	1/7
thyroid	0/2
upper aerodigestive	10/22
urinary tract	9/29
uterus	3/5

Expression Distribution