UniProt Summary: May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation. {ECO:0000250|UniProtKB:Q9EQ80}.
Pfam DomainsGO Terms
Pfam Domains
NIF3
GO Terms
transcription factor binding
neuron differentiation
identical protein binding
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
mitochondrion
negative regulation of RNA metabolic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
generation of neurons
positive regulation of transcription, DNA-templated
negative regulation of biosynthetic process
neurogenesis
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)