NME1-NME2

Gene Information

Official Symbol: N/A
Official Name: N/A
Aliases and Previous Symbols: N/A
Entrez ID: N/A
UniProt: N/A
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: N/A

Function Summary

Entrez Summary: N/A
UniProt Summary: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity. {ECO:0000269|PubMed:15249197, ECO:0000269|PubMed:20946858, ECO:0000269|PubMed:8392752}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Wortmannin 5μM R00 exp38	-2.35
Tunicamycin 0.04μM R07 exp418	-1.87
Cycloheximide 0.2μM R00 exp15	-1.78
UM131593 0.1μM R01 exp58	-1.75
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	-1.72
Combretastatin A4 0.002 to 0.003μM day4 R04 exp179	-1.7
Mdivi-1 15μM R05 exp217	1.7
SNS-032 15μM R08 exp443	1.73
Doxorubicin 0.02μM R08 exp478	1.89

Essentiality in NALM6

Essentiality Rank: 13807
Expression level (log2 read counts): 7.27

Expression Distribution