NVL
Gene Information
- Official Symbol: NVL
- Official Name: nuclear VCP like
- Aliases and Previous Symbols: N/A
- Entrez ID: 4931
- UniProt: O15381
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the AAA (ATPases associated with diverse cellular activities) superfamily. Multiple transcript variants encoding different isoforms have been found for this gene. Two encoded proteins, described as major and minor isoforms, have been localized to distinct regions of the nucleus. The largest encoded protein (major isoform) has been localized to the nucleolus and shown to participate in ribosome biosynthesis (PMID: 15469983, 16782053), while the minor isoform has been localized to the nucleoplasmin. [provided by RefSeq, Aug 2011].
- UniProt Summary: Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT (PubMed:22226966). May play a role in 60S ribosomal subunit biogenesis (PubMed:15469983, PubMed:16782053). {ECO:0000269|PubMed:15469983, ECO:0000269|PubMed:16782053, ECO:0000269|PubMed:22226966}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 274
- Expression level (log2 read counts): 5.95
NVL Expression in NALM6 Cells: 5.95
