NXF3
Gene Information
- Official Symbol: NXF3
- Official Name: nuclear RNA export factor 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 56000
- UniProt: Q9H4D5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus. [provided by RefSeq, Jul 2008].
- UniProt Summary: May function as a tissue-specific nuclear mRNA export factor.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 17850
- Expression level (log2 read counts): -7.68
NXF3 Expression in NALM6 Cells: -7.68
