OSGIN1
Gene Information
- Official Symbol: OSGIN1
- Official Name: oxidative stress induced growth inhibitor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 29948
- UniProt: Q9UJX0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011].
- UniProt Summary: Regulates the differentiation and proliferation of normal cells through the regulation of cell death. {ECO:0000269|PubMed:11459809, ECO:0000269|PubMed:14570898}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 13633
- Expression level (log2 read counts): -1.53
OSGIN1 Expression in NALM6 Cells: -1.53
