PFKFB2
Gene Information
- Official Symbol: PFKFB2
- Official Name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 5208
- UniProt: O60825
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Synthesis and degradation of fructose 2,6-bisphosphate.
Pfam Domains GO Terms
Pfam Domains
| 6PF2K |
| His Phos 1 |
GO Terms
| 6-phosphofructo-2-kinase activity |
| fructose-2,6-bisphosphate 2-phosphatase activity |
| positive regulation of glucokinase activity |
| fructose 2,6-bisphosphate metabolic process |
| positive regulation of hexokinase activity |
| regulation of glucokinase activity |
| regulation of hexokinase activity |
| lactate metabolic process |
| fructose metabolic process |
| positive regulation of glycolytic process |
| carbohydrate phosphorylation |
| glucose catabolic process |
| glycolytic process |
| ATP generation from ADP |
| positive regulation of nucleotide metabolic process |
| positive regulation of purine nucleotide metabolic process |
| positive regulation of ATP metabolic process |
| ADP metabolic process |
| hexose catabolic process |
| positive regulation of cellular carbohydrate metabolic process |
| nucleoside diphosphate phosphorylation |
| purine nucleoside diphosphate metabolic process |
| monosaccharide catabolic process |
| nucleotide phosphorylation |
| purine ribonucleoside diphosphate metabolic process |
| ribonucleoside diphosphate metabolic process |
| pyruvate metabolic process |
| positive regulation of insulin secretion |
| positive regulation of carbohydrate metabolic process |
| regulation of glycolytic process |
| nucleoside diphosphate metabolic process |
| regulation of carbohydrate catabolic process |
| positive regulation of peptide hormone secretion |
| regulation of glucose metabolic process |
| glucose metabolic process |
| regulation of purine nucleotide metabolic process |
| regulation of nucleotide metabolic process |
| carbohydrate catabolic process |
| regulation of ATP metabolic process |
| positive regulation of hormone secretion |
| positive regulation of small molecule metabolic process |
| response to glucose |
| regulation of cellular carbohydrate metabolic process |
| response to hexose |
| response to monosaccharide |
| hexose metabolic process |
| regulation of generation of precursor metabolites and energy |
| cellular carbohydrate metabolic process |
| response to carbohydrate |
| regulation of insulin secretion |
| monosaccharide metabolic process |
| regulation of carbohydrate metabolic process |
| ATP metabolic process |
| regulation of peptide hormone secretion |
| regulation of hormone secretion |
| positive regulation of protein secretion |
| positive regulation of peptide secretion |
| dephosphorylation |
| purine ribonucleotide metabolic process |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| positive regulation of cellular catabolic process |
| purine-containing compound metabolic process |
| positive regulation of secretion by cell |
| generation of precursor metabolites and energy |
| positive regulation of protein transport |
| regulation of small molecule metabolic process |
| positive regulation of catabolic process |
| positive regulation of secretion |
| small molecule catabolic process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| organic hydroxy compound metabolic process |
| positive regulation of establishment of protein localization |
| protein kinase binding |
| regulation of protein secretion |
| carbohydrate metabolic process |
| regulation of peptide secretion |
| monocarboxylic acid metabolic process |
| regulation of hormone levels |
| nucleobase-containing small molecule metabolic process |
| positive regulation of kinase activity |
| positive regulation of transferase activity |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of secretion |
| regulation of cellular catabolic process |
| regulation of kinase activity |
| organophosphate metabolic process |
| carboxylic acid metabolic process |
| regulation of transferase activity |
| positive regulation of transport |
| regulation of catabolic process |
| oxoacid metabolic process |
| organic acid metabolic process |
| regulation of protein localization |
| carbohydrate derivative metabolic process |
| positive regulation of phosphorylation |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| phosphorylation |
| positive regulation of catalytic activity |
| ATP binding |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| small molecule metabolic process |
| organic substance catabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| 5-Fluorouracil 20μM R00 exp2 | -1.81 |
| Selumetinib 20μM R02 exp81 | -1.75 |
| Cincreasin 100μM R08 exp473 | -1.72 |
| NN-Dimethylsphingosine 2.5μM R08 exp508 | 1.89 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18841
- Expression level (log2 read counts): -0.18
Expression Distribution
PFKFB2 Expression in NALM6 Cells: -0.18
