PLAGL2
Gene Information
- Official Symbol: PLAGL2
- Official Name: PLAG1 like zinc finger 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 5326
- UniProt: Q9UPG8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Shows weak transcriptional activatory activity.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| chylomicron assembly |
| plasma lipoprotein particle assembly |
| protein-lipid complex assembly |
| plasma lipoprotein particle organization |
| protein-lipid complex subunit organization |
| positive regulation of intrinsic apoptotic signaling pathway |
| regulation of plasma lipoprotein particle levels |
| post-embryonic development |
| regulation of intrinsic apoptotic signaling pathway |
| positive regulation of apoptotic signaling pathway |
| extracellular structure organization |
| regulation of apoptotic signaling pathway |
| sequence-specific DNA binding |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| RNA biosynthetic process |
| DNA-binding transcription factor activity |
| positive regulation of cell death |
| positive regulation of intracellular signal transduction |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| lipid metabolic process |
| positive regulation of transcription by RNA polymerase II |
| organic cyclic compound biosynthetic process |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| protein-containing complex assembly |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of signal transduction |
| RNA metabolic process |
| regulation of cell death |
| cellular macromolecule biosynthetic process |
| positive regulation of RNA metabolic process |
| macromolecule biosynthetic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Artemisinin 50μM R08 exp450 | 1.7 |
| Latrunculin-B 10μM R07 exp374 | 1.73 |
| iCRT14 30μM R08 exp492 | 1.79 |
| AICAR 240μM R03 exp116 | 1.8 |
| Pyridostatin 4μM R05 exp240 | 2.08 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| GNAS | 0.405 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 1/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6654
- Expression level (log2 read counts): 5.77
Expression Distribution
PLAGL2 Expression in NALM6 Cells: 5.77
