PLCH2
Gene Information
- Official Symbol: PLCH2
- Official Name: phospholipase C eta 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 9651
- UniProt: O75038
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| efhand like |
| C2 |
| PI-PLC-Y |
| PI-PLC-X |
GO Terms
| inositol trisphosphate biosynthetic process |
| inositol trisphosphate metabolic process |
| phosphatidylinositol phospholipase C activity |
| inositol phosphate biosynthetic process |
| release of sequestered calcium ion into cytosol |
| inositol phosphate metabolic process |
| negative regulation of sequestering of calcium ion |
| polyol biosynthetic process |
| calcium ion transmembrane import into cytosol |
| phosphatidylinositol-mediated signaling |
| calcium ion transport into cytosol |
| inositol lipid-mediated signaling |
| cytosolic calcium ion transport |
| polyol metabolic process |
| alcohol biosynthetic process |
| regulation of sequestering of calcium ion |
| phosphatidylinositol metabolic process |
| organic hydroxy compound biosynthetic process |
| calcium ion transmembrane transport |
| calcium ion transport |
| positive regulation of cytosolic calcium ion concentration |
| divalent metal ion transport |
| lipid catabolic process |
| divalent inorganic cation transport |
| glycerophospholipid metabolic process |
| alcohol metabolic process |
| regulation of cytosolic calcium ion concentration |
| phospholipid metabolic process |
| glycerolipid metabolic process |
| cellular calcium ion homeostasis |
| cellular component |
| calcium ion homeostasis |
| organic hydroxy compound metabolic process |
| cellular divalent inorganic cation homeostasis |
| divalent inorganic cation homeostasis |
| organophosphate biosynthetic process |
| cellular metal ion homeostasis |
| inorganic cation transmembrane transport |
| small molecule biosynthetic process |
| cation transmembrane transport |
| metal ion homeostasis |
| cellular cation homeostasis |
| metal ion transport |
| cellular ion homeostasis |
| inorganic ion transmembrane transport |
| cation homeostasis |
| inorganic ion homeostasis |
| calcium ion binding |
| cellular chemical homeostasis |
| molecular function |
| ion homeostasis |
| cation transport |
| organophosphate metabolic process |
| cellular homeostasis |
| ion transmembrane transport |
| cellular lipid metabolic process |
| chemical homeostasis |
| lipid metabolic process |
| transmembrane transport |
| ion transport |
| homeostatic process |
| intracellular signal transduction |
| small molecule metabolic process |
| organic substance catabolic process |
| establishment of localization in cell |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| UM0129480 7μM R02 exp85 | -2.07 |
| Temozolomide 200μM R04 exp189 | -2.01 |
| LJH685 5μM R02 exp73 | -1.83 |
| NFN1 0.1μM R01 exp49 | 1.74 |
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| RRM1 | 0.449 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 14181
- Expression level (log2 read counts): 0.66
Expression Distribution
PLCH2 Expression in NALM6 Cells: 0.66
