PLEKHG2
Gene Information
- Official Symbol: PLEKHG2
- Official Name: pleckstrin homology and RhoGEF domain containing G2
- Aliases and Previous Symbols: N/A
- Entrez ID: 64857
- UniProt: Q9H7P9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a RhoGTPase that can activate CDC42 by promoting exchange of GDP for GTP on CDC42. The encoded protein is activated by binding to the beta and gamma subunits of heterotrimeric guanine nucleotide-binding protein. Defects in this gene have been associated with leukodystrophy and acquired microcephaly with or without dystonia. [provided by RefSeq, May 2017].
- UniProt Summary: May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide- binding protein (G protein) (PubMed:18045877). Involved in the regulation of actin polymerization (PubMed:26573021). {ECO:0000250|UniProtKB:Q6KAU7, ECO:0000269|PubMed:18045877, ECO:0000269|PubMed:26573021}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 2497
- Expression level (log2 read counts): 6.24
PLEKHG2 Expression in NALM6 Cells: 6.24
