POU6F2
Gene Information
- Official Symbol: POU6F2
- Official Name: POU class 6 homeobox 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 11281
- UniProt: P78424
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Oct 2009].
- UniProt Summary: Probable transcription factor likely to be involved in early steps in the differentiation of amacrine and ganglion cells. Recognizes and binds to the DNA sequence 5'-ATGCAAAT-3'. Isoform 1 does not bind DNA.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 5783
- Expression level (log2 read counts): 0.25
POU6F2 Expression in NALM6 Cells: 0.25
