PYGO2
Gene Information
- Official Symbol: PYGO2
- Official Name: pygopus family PHD finger 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 90780
- UniProt: Q9BRQ0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Involved in signal transduction through the Wnt pathway.
Pfam Domains GO Terms
Pfam Domains
| PHD |
GO Terms
| histone acetyltransferase regulator activity |
| beta-catenin-TCF complex |
| positive regulation of chromatin binding |
| regulation of mammary gland epithelial cell proliferation |
| spermatid nucleus differentiation |
| regulation of chromatin binding |
| regulation of histone H3-K4 methylation |
| beta-catenin-TCF complex assembly |
| regulation of histone acetylation |
| regulation of peptidyl-lysine acetylation |
| regulation of histone methylation |
| regulation of protein acetylation |
| lens development in camera-type eye |
| post-embryonic development |
| canonical Wnt signaling pathway |
| roof of mouth development |
| mammary gland development |
| histone binding |
| nucleus organization |
| regulation of histone modification |
| spermatid development |
| spermatid differentiation |
| positive regulation of binding |
| regulation of chromatin organization |
| germ cell development |
| kidney development |
| renal system development |
| camera-type eye development |
| urogenital system development |
| regulation of epithelial cell proliferation |
| regulation of chromosome organization |
| cellular process involved in reproduction in multicellular organism |
| Wnt signaling pathway |
| cell-cell signaling by wnt |
| eye development |
| visual system development |
| sensory system development |
| regulation of binding |
| in utero embryonic development |
| developmental growth |
| growth |
| chromatin binding |
| gland development |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| spermatogenesis |
| sensory organ development |
| male gamete generation |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| developmental process involved in reproduction |
| gamete generation |
| brain development |
| head development |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| embryo development |
| central nervous system development |
| multi-organism reproductive process |
| cell-cell signaling |
| regulation of organelle organization |
| reproductive process |
| reproduction |
| protein-containing complex assembly |
| regulation of cell population proliferation |
| cell development |
| positive regulation of molecular function |
| regulation of protein modification process |
| protein-containing complex subunit organization |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
Most Correlated Genes in Chemogenomics
| Gene | Correlation |
|---|---|
| LEF1 | 0.401 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9390
- Expression level (log2 read counts): 5.27
Expression Distribution
PYGO2 Expression in NALM6 Cells: 5.27
