RFC3
Gene Information
- Official Symbol: RFC3
- Official Name: replication factor C subunit 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 5983
- UniProt: P40938
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1.
Pfam Domains GO Terms
Pfam Domains
| RFC-E C |
| AAA |
GO Terms
| DNA replication factor C complex |
| positive regulation of DNA-directed DNA polymerase activity |
| regulation of DNA-directed DNA polymerase activity |
| Ctf18 RFC-like complex |
| DNA clamp loader activity |
| single-stranded DNA helicase activity |
| DNA strand elongation involved in DNA replication |
| error-prone translesion synthesis |
| error-free translesion synthesis |
| DNA strand elongation |
| nucleotide-excision repair, DNA gap filling |
| telomere maintenance via semi-conservative replication |
| nucleotide-excision repair, DNA incision, 5-to lesion |
| DNA damage response, detection of DNA damage |
| nucleotide-excision repair, DNA incision |
| translesion synthesis |
| nuclear DNA replication |
| cell cycle DNA replication |
| DNA synthesis involved in DNA repair |
| postreplication repair |
| regulation of DNA-dependent DNA replication |
| positive regulation of DNA biosynthetic process |
| transcription-coupled nucleotide-excision repair |
| telomere maintenance |
| telomere organization |
| regulation of DNA replication |
| DNA biosynthetic process |
| nucleotide-excision repair |
| DNA duplex unwinding |
| regulation of DNA biosynthetic process |
| DNA geometric change |
| DNA-dependent DNA replication |
| response to organophosphorus |
| regulation of signal transduction by p53 class mediator |
| positive regulation of DNA metabolic process |
| DNA replication |
| ATPase activity |
| DNA conformation change |
| nucleic acid phosphodiester bond hydrolysis |
| anatomical structure homeostasis |
| regulation of DNA metabolic process |
| DNA repair |
| positive regulation of transferase activity |
| detection of stimulus |
| DNA metabolic process |
| cellular response to DNA damage stimulus |
| cellular homeostasis |
| regulation of transferase activity |
| cell cycle process |
| chromosome organization |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| organic cyclic compound biosynthetic process |
| cell cycle |
| positive regulation of catalytic activity |
| DNA binding |
| cellular nitrogen compound biosynthetic process |
| homeostatic process |
| cellular response to stress |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| regulation of intracellular signal transduction |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Talazoparib 0.006μM R06 exp299 | -2.62 |
| Olaparib 4μM R08 exp512 | -2.25 |
| Hydroxyurea 100μM R07 exp329 | -2.21 |
| Disulfiram 4.3μM R06 exp281 | -1.84 |
| MS023 7μM R03 exp135 | -1.79 |
| DABN racemic mixture R03 exp93 | -1.75 |
| Aminopterin 0.005μM R07 exp335 | -1.74 |
| Bisphenol A 100μM R06 exp269 | -1.7 |
| UNC2400 2μM R03 exp156 | 1.81 |
| Glyphosate 1000μM R06 exp283 | 1.94 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 734/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 1/1 |
| bile duct | 28/28 |
| blood | 28/28 |
| bone | 26/26 |
| breast | 32/33 |
| central nervous system | 56/56 |
| cervix | 4/4 |
| colorectal | 16/17 |
| esophagus | 13/13 |
| fibroblast | 1/1 |
| gastric | 16/16 |
| kidney | 21/21 |
| liver | 20/20 |
| lung | 75/75 |
| lymphocyte | 15/16 |
| ovary | 25/26 |
| pancreas | 24/24 |
| peripheral nervous system | 16/16 |
| plasma cell | 15/15 |
| prostate | 1/1 |
| skin | 23/24 |
| soft tissue | 9/9 |
| thyroid | 2/2 |
| upper aerodigestive | 22/22 |
| urinary tract | 29/29 |
| uterus | 5/5 |
Essentiality in NALM6
- Essentiality Rank: 221
- Expression level (log2 read counts): 6.48
Expression Distribution
RFC3 Expression in NALM6 Cells: 6.48
