Pfam Domains GO Terms
| Rad17 |
| AAA |
| Rep fac C |
| DNA replication factor C complex |
| positive regulation of DNA-directed DNA polymerase activity |
| regulation of DNA-directed DNA polymerase activity |
| Ctf18 RFC-like complex |
| DNA clamp loader activity |
| single-stranded DNA helicase activity |
| error-prone translesion synthesis |
| error-free translesion synthesis |
| nucleotide-excision repair, DNA gap filling |
| telomere maintenance via semi-conservative replication |
| nucleotide-excision repair, DNA incision, 5-to lesion |
| DNA damage response, detection of DNA damage |
| nucleotide-excision repair, DNA incision |
| translesion synthesis |
| nuclear DNA replication |
| cell cycle DNA replication |
| DNA synthesis involved in DNA repair |
| postreplication repair |
| regulation of DNA-dependent DNA replication |
| positive regulation of DNA biosynthetic process |
| transcription-coupled nucleotide-excision repair |
| telomere maintenance |
| telomere organization |
| regulation of DNA replication |
| DNA biosynthetic process |
| nucleotide-excision repair |
| DNA duplex unwinding |
| regulation of DNA biosynthetic process |
| DNA geometric change |
| DNA-dependent DNA replication |
| regulation of signal transduction by p53 class mediator |
| positive regulation of DNA metabolic process |
| DNA replication |
| DNA conformation change |
| nucleic acid phosphodiester bond hydrolysis |
| anatomical structure homeostasis |
| enzyme binding |
| regulation of DNA metabolic process |
| DNA repair |
| positive regulation of transferase activity |
| detection of stimulus |
| DNA metabolic process |
| cellular response to DNA damage stimulus |
| cellular homeostasis |
| regulation of transferase activity |
| cell cycle process |
| chromosome organization |
| nucleobase-containing compound biosynthetic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| organic cyclic compound biosynthetic process |
| cell cycle |
| positive regulation of catalytic activity |
| ATP binding |
| cellular nitrogen compound biosynthetic process |
| homeostatic process |
| cellular response to stress |
| cellular macromolecule biosynthetic process |
| macromolecule biosynthetic process |
| positive regulation of molecular function |
| regulation of intracellular signal transduction |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
| Screen | Score |
|---|---|
| Aminopterin 0.005μM R07 exp335 | -2.14 |
| Talazoparib 0.006μM R06 exp299 | -2.1 |
| Rucaparib 6.5μM R08 exp520 | -2.05 |
| DABN 2μM R00 exp16 | -1.86 |
| Arsenic trioxide 60μM R08 exp449 | -1.79 |
| SB202190 10μM R03 exp148 | -1.78 |
| Olaparib 4μM R08 exp512 | -1.7 |
| Daidzin 10μM R06 exp280 | 2.33 |
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 1/1 |
| bile duct | 20/28 |
| blood | 26/28 |
| bone | 23/26 |
| breast | 25/33 |
| central nervous system | 45/56 |
| cervix | 4/4 |
| colorectal | 10/17 |
| esophagus | 9/13 |
| fibroblast | 1/1 |
| gastric | 10/16 |
| kidney | 17/21 |
| liver | 16/20 |
| lung | 55/75 |
| lymphocyte | 13/16 |
| ovary | 21/26 |
| pancreas | 14/24 |
| peripheral nervous system | 14/16 |
| plasma cell | 12/15 |
| prostate | 0/1 |
| skin | 12/24 |
| soft tissue | 8/9 |
| thyroid | 2/2 |
| upper aerodigestive | 12/22 |
| urinary tract | 22/29 |
| uterus | 5/5 |
Expression Distribution